ArticleBMC neuroscience2012
Neuroglobin-overexpression reduces traumatic brain lesion size in mice.
Article in BMC neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The therapeutic potential of neuroglobin-overexpressing human neural stem cells in a photothrombosis model.Regenerative therapy · 2025Article
- Neuroglobin and Cytoglobin in Mammalian Nervous Systems: About Distribution, Regulation, Function, and Some Open Questions.Brain sciences · 2025Review
- Mitochondrial-targeted therapies in traumatic brain injury: From bench to bedside.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Neuroglobin Is Involved in the Hypoxic Stress Response in the Brain.BioMed research international · 2022Article
- Expression and distribution of neuroglobin and hypoxia-inducible factor-1α in the adult yak telencephalon.Veterinary medicine and science · 2021Article
- Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds.Cells · 2021Review
- Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury.Molecular neurobiology · 2019Article
- Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation.Molecular neurobiology · 2019Review
- Neuroglobin Expression Models as a Tool to Study Its Function.Oxidative medicine and cellular longevity · 2019Review
- Neuroglobin promotes neurogenesis through Wnt signaling pathway.Cell death & disease · 2018Article
- Neuroglobin Regulates Wnt/β-Catenin and NFκB Signaling Pathway through Dvl1.International journal of molecular sciences · 2018Article
- Blockade of Neuroglobin Reduces Protection of Conditioned Medium from Human Mesenchymal Stem Cells in Human Astrocyte Model (T98G) Under a Scratch Assay.Molecular neurobiology · 2018Article
- Neuroimmune-Driven Neuropathic Pain Establishment: A Focus on Gender Differences.International journal of molecular sciences · 2018Review
- Neuroglobin Protects Rats from Sepsis-Associated Encephalopathy via a PI3K/Akt/Bax-Dependent Mechanism.Journal of molecular neuroscience : MN · 2017Article
- Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice.International journal of medical sciences · 2017Article
- Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury.Cellular and molecular neurobiology · 2016Article
- Protection by Neuroglobin Expression in Brain Pathologies.Frontiers in neurology · 2016Review
- Neuroglobin overexpression improves sensorimotor outcomes in a mouse model of traumatic brain injury.Neuroscience letters · 2014Article
- Expression and cell distribution of neuroglobin in the brain tissue after experimental subarachnoid hemorrhage in rats: a pilot study.Cellular and molecular neurobiology · 2014Article
- The role of neuroglobin in the neuroprotection of limb ischemic preconditioning in rats.Molecular neurobiology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAccumulating evidence has demonstrated that over-expression of Neuroglobin (Ngb) is neuroprotective against hypoxic/ischemic brain injuries. In this study we tested the neuroprotective effects of Ngb over-expression against traumatic brain injury (TBI) in mice.
resultsBoth Ngb over-expression transgenic (Ngb-Tg) and wild-type (WT) control mice were subjected to TBI induced by a controlled cortical impact (CCI) device. TBI significantly increased Ngb expression in the brains of both WT and Ngb-Tg mice, but Ngb-Tg mice had significantly higher Ngb protein levels at the pre-injury baseline and post-TBI. Production of oxidative tissue damage biomarker 3NT in the brain was significantly reduced in Ngb-Tg mice compared to WT controls at 6 hours after TBI. The traumatic brain lesion volume was significantly reduced in Ngb Tg mice compared to WT mice at 3 weeks after TBI; however, there were no significant differences in the recovery of sensorimotor and spatial memory functional deficits between Ngb-Tg and WT control mice for up to 3 weeks after TBI.
conclusionNgb over-expression reduced traumatic lesion volume, which might partially be achieved by decreasing oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.