ArticleJournal of anatomy2012
Regional variations in the distribution and colocalization of extracellular matrix proteins in the juvenile bovine meniscus.
Article in Journal of anatomy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Spatial Characterization of the Human Meniscus: Bridging Biomechanics and Biochemistry Using Atomic Force Microscopy Micro-Indentation and Mass Spectrometry Imaging.Small methods · 2026Article
- Recombinant Small Leucine-Rich Proteoglycans Modulate Fiber Structure and Mechanical Properties of Collagen Gels.ACS biomaterials science & engineering · 2025Article
- siRNA Treatment Enhances Collagen Fiber Formation in Tissue-Engineered Meniscus via Transient Inhibition of Aggrecan Production.Bioengineering (Basel, Switzerland) · 2024Article
- In Situ Loading and Time-Resolved Synchrotron-Based Phase Contrast Tomography for the Mechanical Investigation of Connective Knee Tissues: A Proof-of-Concept Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advanced glycation end-product accumulation differs by location and sex in aged osteoarthritic human menisci.Osteoarthritis and cartilage · 2023Article
- Meniscus heterogeneity and 3D-printed strategies for engineering anisotropic meniscus.International journal of bioprinting · 2023Article
- Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells.Biomedicines · 2022Article
- Prospective Application of Partially Digested Autologous Chondrocyte for Meniscus Tissue Engineering.Pharmaceutics · 2022Article
- Type V collagen regulates the structure and biomechanics of TMJ condylar cartilage: A fibrous-hyaline hybrid.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- Intrinsic and growth-mediated cell and matrix specialization during murine meniscus tissue assembly.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Nuclear envelope wrinkling predicts mesenchymal progenitor cell mechano-response in 2D and 3D microenvironments.Biomaterials · 2021Article
- Decorin regulates cartilage pericellular matrix micromechanobiology.Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis.Acta biomaterialia · 2020Article
- Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages.Stem cells translational medicine · 2019Article
- Identification of Pivotal Genes and Pathways in Osteoarthritic Degenerative Meniscal Lesions via Bioinformatics Analysis of the GSE52042 Dataset.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Impacts of maturation on the micromechanics of the meniscus extracellular matrix.Journal of biomechanics · 2018Article
- AFM-Nanomechanical Test: An Interdisciplinary Tool That Links the Understanding of Cartilage and Meniscus Biomechanics, Osteoarthritis Degeneration, and Tissue Engineering.ACS biomaterials science & engineering · 2017Article
- Next Generation Tissue Engineering of Orthopedic Soft Tissue-to-Bone Interfaces.MRS communications · 2017Article
- Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix.Acta biomaterialia · 2017Article
- Anatomical region-dependent enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix.Acta biomaterialia · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A deeper understanding of the composition and organization of extracellular matrix molecules in native, healthy meniscus tissue is required to fully appreciate the degeneration that occurs in joint disease and the intricate environment in which an engineered meniscal graft would need to function. In this study, regional variations in the tissue-level and pericellular distributions of collagen types I, II and VI and the proteoglycans aggrecan, biglycan and decorin were examined in the juvenile bovine meniscus. The collagen networks were extensively, but not completely, colocalized, with tissue-level organization that varied with radial position across the meniscus. Type VI collagen exhibited close association with large bundles composed of type I and II collagen and, in contrast to type I and II collagen, was further concentrated in the pericellular matrix. Aggrecan was detected throughout the inner region of the meniscus but was restricted to the pericellular matrix and sheaths of collagen bundles in the middle and outer regions. The small proteoglycans biglycan and decorin exhibited regional variations in staining intensity but were consistently localized in the intra- and/or peri-cellular compartments. These results provide insight into the complex hierarchy of extracellular matrix organization in the meniscus and provide a framework for better understanding meniscal degeneration and disease progression and evaluating potential repair and regeneration strategies.
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