Trial reportBJOG : an international journal of obstetrics and gynaecology2012
Should cervical favourability play a role in the decision for labour induction in gestational hypertension or mild pre-eclampsia at term? An exploratory analysis of the HYPITAT trial.
Trial report in BJOG : an international journal of obstetrics and gynaecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Delivery or expectant management for prevention of adverse maternal and neonatal outcomes in hypertensive disorders of pregnancy: an individual participant data meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2019Pooled it
- Planned early delivery versus expectant management for hypertensive disorders from 34 weeks gestation to term.The Cochrane database of systematic reviews · 2017Pooled it
- Women's Experiences of Induction of Labor and Birth After Prolonged Medical Induction: A Qualitative Study From Denmark.Birth (Berkeley, Calif.) · 2025Article
- Article
- Article
- Evaluation of biomarkers for treatment selection using individual participant data from multiple clinical trials.Statistics in medicine · 2018Article
- Cervical Evaluation: From Ancient Medicine to Precision Medicine.Obstetrics and gynecology · 2017Article
- Timing of delivery and pregnancy outcomes in women with gestational diabetes.American journal of obstetrics and gynecology · 2016Article
- Pre-eclampsia part 2: prediction, prevention and management.Nature reviews. Nephrology · 2014Review
- Labour induction with gestational hypertension: A great obstetric challenge.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 14 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether cervical favourability (measured by cervical length and the Bishop score) should inform obstetricians' decision regarding labour induction for women with gestational hypertension or mild pre-eclampsia at term.
designA post hoc analysis of the Hypertension and Pre-eclampsia Intervention Trial At Term (HYPITAT).
settingObstetric departments of six university and 32 teaching and district hospitals in the Netherlands. POPULATION: A total of 756 women diagnosed with gestational hypertension or pre-eclampsia between 36 + 0 and 41 + 0 weeks of gestation randomly allocated to induction of labour or expectant management.
methodsData were analysed using logistic regression modelling.
main outcome measuresThe occurrence of a high-risk maternal situation defined as either maternal complications or progression to severe disease. Secondary outcomes were caesarean delivery and adverse neonatal outcomes.
resultsThe superiority of labour induction in preventing high-risk situations in women with gestational hypertension or mild pre-eclampsia at term varied significantly according to cervical favourability. In women who were managed expectantly, the longer the cervix the higher the risk of developing maternal high-risk situations, whereas in women in whom labour was induced, cervical length was not associated with a higher probability of maternal high-risk situations (test of interaction P = 0.03). Similarly, the beneficial effect of labour induction on reducing the caesarean section rate was stronger in women with an unfavourable cervix.
conclusionAgainst widely held opinion, our exploratory analysis showed that women with gestational hypertension or mild pre-eclampsia at term who have an unfavourable cervix benefited more from labour induction than other women.
trial registrationThe trial has been registered in the clinical trial register as ISRCTN08132825.
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