ArticleJournal of the American Chemical Society2012
Evidence for helical structure in a tetramer of α2-8 sialic acid: unveiling a structural antigen.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity.FEBS letters · 2025Article
- Synthesis of a glycan hairpin.Nature chemistry · 2023Article
- Primary Structure of Glycans by NMR Spectroscopy.Chemical reviews · 2023Review
- Synthetic Approaches to Break the Chemical Shift Degeneracy of Glycans.Chembiochem : a European journal of chemical biology · 2022Article
- Methods for Measuring Exchangeable Protons in Glycosaminoglycans.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Incorporation of Labile Protons into Multidimensional NMR Analyses: Glycan Structures Revisited.Journal of the American Chemical Society · 2021Article
- Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling.Frontiers in molecular biosciences · 2021Review
- Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids.Nature communications · 2020Article
- Conformational properties of l-fucose and the tetrasaccharide building block of the sulfated l-fucan from Lytechinus variegatus.Journal of structural biology · 2020Article
- Molecular Conformations of Di-, Tri-, and Tetra-International journal of molecular sciences · 2019Article
- The capsule ofVirulence · 2019Review
- A Solution NMR Approach To Determine the Chemical Structures of Carbohydrates Using the Hydroxyl Groups as Starting Points.ACS omega · 2018Article
- Predicting the Structures of Glycans, Glycoproteins, and Their Complexes.Chemical reviews · 2018Review
- Capture of PbBiomolecules · 2018Article
- Polysialic acid is a cellular receptor for human adenovirus 52.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Physical biology of the cancer cell glycocalyx.Nature physics · 2018Article
- The β-reducing end in α(2-8)-polysialic acid constitutes a unique structural motif.Glycobiology · 2017Article
- Exploiting UniformlyJournal of the American Chemical Society · 2017Article
- NMR structure analysis of uniformly 13C-labeled carbohydrates.Journal of biomolecular NMR · 2014Article
- Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration.Physiological reviews · 2014Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Characteristic H-bonding patterns define secondary structure in proteins and nucleic acids. We show that similar patterns apply for α2-8 sialic acid (SiA) in H(2)O and that H-bonds define its structure. A (15)N,(13)C α2-8 SiA tetramer, (SiA)(4), was used as a model system for the polymer. At 263 K, we detected intra-residue through-H-bond J couplings between (15)N and C8 for residues R-I-R-III of the tetramer, indicating H-bonds between the (15)N's and the O8's of these residues. Additional J couplings between the (15)N's and C2's of the adjacent residues confirm the putative H-bonds. NH groups showing this long-range correlation also experience slower (1)H/(2)H exchange. Additionally, detection of couplings between H7 and C2 for R-II and R-III implies that the conformations of the linkers between these residues are different than in the monomers. These structural elements are consistent with two left-handed helical models: 2 residues/turn (2(4) helix) and 4 residues/turn (1(4) helix). To discriminate between models, we resorted to (1)H,(1)H NOEs. The 2(4) helical model is in better agreement with the experimental data. We provide direct evidence of H-bonding for (SiA)(4) and show how H-bonds can be a determining factor for shaping its 3D structure.
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Registered trials
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