Evidence map›Paper›PMID 22702899›Full record

ArticleProtein and peptide letters2012

Water-refined solution structure of the human Grb7-SH2 domain in complex with the erbB2 receptor peptide pY1139.

Sally C Pias, Dennis L Johnson, David E Smith, Barbara A Lyons

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein and peptide letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sally C PiasDepartment of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003-8001, USA.
Dennis L Johnson
David E Smith
Barbara A Lyons
New Mexico State University · US

Funding

ZUNI HEALTH INITIATIVE-PILOT STUDYP20RR016480 · NCRR · NEW MEXICO STATE UNIVERSITY LAS CRUCES · PI ZHANG, PENG F · 2001 to 2011
$33.7M
Research Education About Cancer and Health (REACH) CoreU54CA132381 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KAREN R PETERSON · 2007 to 2026
$25.3M
NCI NIH HHS U54 CA132381NCRR NIH HHS P20 RR016480NCRR NIH HHS P20RR016480
6 · The paper itself

Abstract

We report a refinement in implicit water of the previously published solution structure of the Grb7-SH2 domain bound to the erbB2 receptor peptide pY1139. Structure quality measures indicate substantial improvement, with residues in the most favored regions of the Ramachandran plot increasing by 14 % and with WHAT IF statistics (Vriend, G. J. Mol. Graph., 1990, 8(1), 52-56) falling closer to expected values for well-refined structures.

Indexed as

Protein Conformationsrc Homology DomainsBinding SitesCrystallography, X-RayErb-b2 Receptor Tyrosine KinasesGRB7 Adaptor ProteinHumansLigandsMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularProtein BindingProtein MultimerizationReceptors, PeptideSolutionsWaterERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGRB7 Adaptor ProteinGRB7 protein, humanLigandsReceptors, PeptideSolutionsWater

Identifiers

PMID22702899
PMCPMC3758482
OpenAlexW2153220216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.