ArticleJournal of the American Geriatrics Society2012
Glycosylated hemoglobin and functional decline in community-dwelling nursing home-eligible elderly adults with diabetes mellitus.
Article in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Evidence gap on antihyperglycemic pharmacotherapy in frail older adults : A systematic review.Zeitschrift fur Gerontologie und Geriatrie · 2021Pooled it
- The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: a report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society.Diabetology international · 2018Guideline
- Glycaemic outcomes of an Individualized treatMent aPproach for oldER vulnerable patIents: A randomized, controlled stUdy in type 2 diabetes Mellitus (IMPERIUM).Diabetes, obesity & metabolism · 2018Trial
- Sex Differences in Failure to Achieve Geriatric-Adjusted Glycemic Targets Among Older Adults with Type 2 Diabetes in Vietnam.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Correlation of Waist Circumference-Mediated Glycosylated Hemoglobin Levels With New-Onset BADL Disability.Journal of diabetes research · 2026Article
- The relationship between DASC-8 categories and the effectiveness of education on insulin self-injection techniques in elderly patients with diabetes.Diabetology international · 2024Article
- Comparison of multiple linear regression and machine learning methods in predicting cognitive function in older Chinese type 2 diabetes patients.BMC neurology · 2024Article
- Multimorbidity and Functional Disability among Older Adults: The Role of Inflammation and Glycemic Status - An Observational Longitudinal Study.Gerontology · 2023Observational
- Review on the management of cardiovascular risk factors in the elderly.Journal of geriatric cardiology : JGC · 2022Article
- Hypoglycaemic therapy in frail older people with type 2 diabetes mellitus-a choice determined by metabolic phenotype.Aging clinical and experimental research · 2022Review
- Effects of colchicine use on ischemic and hemorrhagic stroke risk in diabetic patients with and without gout.Scientific reports · 2022Article
- Effects of dipeptidyl peptidase-4 inhibitors and sulphonylureas on cognitive and physical function in nursing home residents.Diabetes, obesity & metabolism · 2022Article
- Kidney Function and Risk of Physical and Cognitive Impairment in Older Persons with Type 2 Diabetes at an Outpatient Clinic with Geriatric Assessment Implementation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Type 2 diabetes mellitus in older adults: clinical considerations and management.Nature reviews. Endocrinology · 2021Review
- Identifying sustainable lifestyle strategies for maintaining good glycemic control: a validation of qualitative findings.BMJ open diabetes research & care · 2021Article
- Not Only Diabetes but Also Prediabetes Leads to Functional Decline and Disability in Older Adults.Diabetes care · 2021Article
- Fingerstick Glucose Monitoring in Veterans Affairs Nursing Home Residents with Diabetes Mellitus.Journal of the American Geriatrics Society · 2021Article
- Low calf circumference is associated with frailty in diabetic adults aged over 80 years.BMC geriatrics · 2020Article
- Glucose control and cognitive and physical function in adults 80+ years of age with diabetes.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Prevalence of prediabetes and type 2 diabetes in two non-random populations aged 44-77 years in the Faroe Islands.Journal of clinical & translational endocrinology · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo determine whether glycosylated hemoglobin (HbA1c) levels predict functional decline in older adults.
designLongitudinal cohort study.
participantsCommunity-dwelling, nursing home (NH)-eligible individuals with diabetes mellitus enrolled at On Lok between October 2002 and December 2008 (367 participants, 1,579 HbA1c measurements).
settingOn Lok Lifeways, the original model for Programs of All-Inclusive Care for the Elderly. MEASUREMENTS: The outcomes were functional decline or death at 2 years. The primary predictor was HbA1c. Age, sex, race and ethnicity, baseline function, comorbid conditions, length of time enrolled at On Lok, insulin use, and clustering of HbA1c within participants were adjusted for with mixed-effects Poisson regression.
resultsMean age was 80, and 185 participants (50%) were taking insulin. Sixty-three percent of participants experienced functional decline, and 75% experienced death or functional decline during the study period. At 2 years, higher HbA1c was associated with less functional decline or death (P for trend = .006). Accounting for clustering and confounding factors, HbA1c of 8.0% to 8.9% was associated with a lower likelihood (relative risk = 0.88, 95% confidence interval = 0.79-0.99) of functional decline or death than HbA1c of 7.0% to 7.9%.
conclusionIn community-dwelling, NH-eligible individuals with diabetes mellitus, HbA1c of 8.0% to 8.9% is associated with better functional outcomes at 2 years than HbA1c of 7.0% to 7.9%, suggesting that the current American Geriatrics Society guideline recommending a HbA1c target of 8.0% or less for older adults with limited life expectancy may be lower than necessary to maintain function.
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