ArticleTranslational gastrointestinal cancer2012
Mechanisms for nicotine in the development and progression of gastrointestinal cancers.
Article in Translational gastrointestinal cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Alternative medicines in oncology: a focus on natural products against gastric cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Common Risk Factors in Gastrointestinal Cancers: A Narrative Review.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- Lifestyle Behaviors in Patients With Gastric Cancer: Continuous Need for Alcohol Abstinence and Muscle Strength Training Education.Journal of gastric cancer · 2024Article
- Updated Epidemiology of Gastric Cancer in Asia: Decreased Incidence but Still a Big Challenge.Cancers · 2023Review
- Molecular mechanisms underlying the action of carcinogens in gastric cancer with a glimpse into targeted therapy.Cellular oncology (Dordrecht, Netherlands) · 2022Review
- Factors Associated With Geographic Disparities in Gastrointestinal Cancer Mortality in the United States.Gastroenterology · 2022Article
- Review
- Epidemiology and biology of early onset colorectal cancer.EXCLI journal · 2022Review
- New Insights into Oral Cancer-Risk Factors and Prevention: A Review of Literature.International journal of preventive medicine · 2020Review
- Nicotine reduces effectiveness of doxorubicin chemotherapy and promotes CD44Experimental and therapeutic medicine · 2018Article
- Effects of interactions between common genetic variants and smoking on colorectal cancer.BMC cancer · 2017Article
- Comprehensive review of epidemiological and animal studies on the potential carcinogenic effects of nicotine per se.Critical reviews in toxicology · 2016Review
- Curcumin protects against nicotine-induced stress during protein malnutrition in female rat through immunomodulation with cellular amelioration.Molecular biology reports · 2015Article
- Association of MMP7 -181A→G Promoter Polymorphism with Gastric Cancer Risk: INFLUENCE OF NICOTINE IN DIFFERENTIAL ALLELE-SPECIFIC TRANSCRIPTION VIA INCREASED PHOSPHORYLATION OF cAMP-RESPONSE ELEMENT-BINDING PROTEIN (CREB).The Journal of biological chemistry · 2015Article
- Colorectal carcinogenesis--update and perspectives.World journal of gastroenterology · 2014Review
- Nicotine alters the proteome of two human pancreatic duct cell lines.JOP : Journal of the pancreas · 2014Article
- Nicotine upregulates microRNA-21 and promotes TGF-β-dependent epithelial-mesenchymal transition of esophageal cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Connections of nicotine to cancer.Nature reviews. Cancer · 2014Review
- Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- The complexities of epidemiology and prevention of gastrointestinal cancers.International journal of molecular sciences · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Long-term smoking is major risk factor for a variety of cancers, including those of the gastrointestinal (GI) tract. Historically, nicotine and its derivatives are well known for their role in addiction, and have more recently been documented for their carcinogenic role in a number of human cancers. The cellular and molecular pathways activated by nicotine mimic physiological and environmental carcinogenesis in cancers throughout the GI tract potentiating cancer growth and/or inducing the formation of cancer on their own. Thus, it is important to unlock the carcinogenic mechanisms induced by nicotine in these systems, and underscore nicotine's potential as an environmental hazard. This review outlines the specific pathways demonstrated to mediate nicotine's carcinogenic mechanism in the GI tract. The abundance of cell and animal evidence calls for increased epidemiologic and case-control evaluation of nicotine's role in cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.