ArticlePloS one2012
Frontal non-invasive neurostimulation modulates antisaccade preparation in non-human primates.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Human-relevant transcranial magnetic stimulation in awake rhesus macaques assisted by a non-invasive head and arm fixation apparatus.iScience · 2026Article
- Covariations between pupil diameter and supplementary eye field activity suggest a role in cognitive effort implementation.PLoS biology · 2022Article
- Ketamine reduces temporal expectation in the rhesus monkey.Psychopharmacology · 2021Article
- Functional ultrasound imaging of deep visual cortex in awake nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Methods matter: A primer on permanent and reversible interference techniques in animals for investigators of human neuropsychology.Neuropsychologia · 2018Review
- Combined rTMS/fMRI Studies: An Overlooked Resource in Animal Models.Frontiers in neuroscience · 2018Review
- Ups and downs in catch-up saccades following single-pulse TMS-methodological considerations.PloS one · 2018Article
- A subanesthetic dose of ketamine in the Rhesus monkey reduces the occurrence of anticipatory saccades.Psychopharmacology · 2015Article
- Non-invasive primate head restraint using thermoplastic masks.Journal of neuroscience methods · 2015Article
- Electric Field Model of Transcranial Electric Stimulation in Nonhuman Primates: Correspondence to Individual Motor Threshold.IEEE transactions on bio-medical engineering · 2015Article
- Rapid-response impulsivity: definitions, measurement issues, and clinical implications.Personality disorders · 2015Review
- The cortex is in overall control of 'voluntary' eye movement.Eye (London, England) · 2015Review
- Transcranial magnetic stimulation of the prefrontal cortex in awake nonhuman primates evokes a polysynaptic neck muscle response that reflects oculomotor activity at the time of stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Frontal eye field, where art thou? Anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations.Frontiers in integrative neuroscience · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
A combination of oculometric measurements, invasive electrophysiological recordings and microstimulation have proven instrumental to study the role of the Frontal Eye Field (FEF) in saccadic activity. We hereby gauged the ability of a non-invasive neurostimulation technology, Transcranial Magnetic Stimulation (TMS), to causally interfere with frontal activity in two macaque rhesus monkeys trained to perform a saccadic antisaccade task. We show that online single pulse TMS significantly modulated antisaccade latencies. Such effects proved dependent on TMS site (effects on FEF but not on an actively stimulated control site), TMS modality (present under active but not sham TMS on the FEF area), TMS intensity (intensities of at least 40% of the TMS machine maximal output required), TMS timing (more robust for pulses delivered at 150 ms than at 100 post target onset) and visual hemifield (relative latency decreases mainly for ipsilateral AS). Our results demonstrate the feasibility of using TMS to causally modulate antisaccade-associated computations in the non-human primate brain and support the use of this approach in monkeys to study brain function and its non-invasive neuromodulation for exploratory and therapeutic purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.