ArticlePloS one2012
Gene expression changes in the septum: possible implications for microRNAs in sculpting the maternal brain.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Distinct patterns of gene expression in the medial preoptic area are related to gregarious singing behavior in European starlings (Sturnus vulgaris).BMC neuroscience · 2023Article
- Transcriptomics of Parental Care in the Hypothalamic-Septal Region of Female Zebra Finch Brain.International journal of molecular sciences · 2022Article
- Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.Genes, brain, and behavior · 2020Article
- Evidence for functional interactions between the placenta and brain in pregnant mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Down-regulation of fatty acid binding protein 7 (Fabp7) is a hallmark of the postpartum brain.Journal of chemical neuroanatomy · 2018Article
- The circadian gene Nr1d1 in the mouse nucleus accumbens modulates sociability and anxiety-related behaviour.The European journal of neuroscience · 2018Article
- Genetic and neuroendocrine regulation of the postpartum brain.Frontiers in neuroendocrinology · 2016Review
- MicroRNA expression is altered in lateral septum across reproductive stages.Neuroscience · 2016Article
- An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period.G3 (Bethesda, Md.) · 2015Article
- Metabotropic glutamate receptor 3 is downregulated and its expression is shifted from neurons to astrocytes in the mouse lateral septum during the postpartum period.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- Glutamate, GABA, and glutamine are synchronously upregulated in the mouse lateral septum during the postpartum period.Brain research · 2014Article
- Genes showing altered expression in the medial preoptic area in the highly social maternal phenotype are related to autism and other disorders with social deficits.BMC neuroscience · 2014Article
- Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens.Frontiers in behavioral neuroscience · 2014Article
- Medial prefrontal cortex: genes linked to bipolar disorder and schizophrenia have altered expression in the highly social maternal phenotype.Frontiers in behavioral neuroscience · 2014Article
- Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.PloS one · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The transition from the non-maternal to the maternal state is characterized by a variety of CNS alterations that support the care of offspring. The septum (including lateral and medial portions) is a brain region previously linked to various emotional and motivational processes, including maternal care. In this study, we used microarrays (PLIER algorithm) to examine gene expression changes in the septum of postpartum mice and employed gene set enrichment analysis (GSEA) to identify possible regulators of altered gene expression. Genes of interest identified as differentially regulated with microarray analysis were validated with quantitative real-time PCR. We found that fatty acid binding protein 7 (Fabp7) and galanin (Gal) were downregulated, whereas insulin-like growth factor binding protein 3 (Igfbp3) was upregulated in postpartum mice compared to virgin females. These genes were previously found to be differentially regulated in other brain regions during lactation. We also identified altered expression of novel genes not previously linked to maternal behavior, but that could play a role in postpartum processes, including glutamate-ammonia ligase (Glul) and somatostatin receptor 1 (Sstr1) (both upregulated in postpartum). Genes implicated in metabolism, cell differentiation, or proliferation also exhibited altered expression. Unexpectedly, enrichment analysis revealed a high number of microRNAs, transcription factors, or conserved binding sites (177 with corrected P-value <0.05) that were significantly linked to maternal upregulated genes, while none were linked to downregulated genes. MicroRNAs have been linked to placenta and mammary gland development, but this is the first indication they may also play a key role in sculpting the maternal brain. Together, this study provides new insights into genes (along with possible mechanisms for their regulation) that are involved in septum-mediated adaptations during the postpartum period.
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