ArticlePloS one2012
VirF-independent regulation of Shigella virB transcription is mediated by the small RNA RyhB.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025Article
- A Tale aboutMicroorganisms · 2023Review
- Roles of Two-Component Signal Transduction Systems in Shigella Virulence.Biomolecules · 2022Review
- Comparative Analysis of Human and Animal E. coli: Serotyping, Antimicrobial Resistance, and Virulence Gene ProfilingAntibiotics (Basel, Switzerland) · 2022Article
- TheFrontiers in molecular biosciences · 2022Review
- Positive regulation of Type III secretion effectors and virulence by RyhB paralogs in Salmonella enterica serovar Enteritidis.Veterinary research · 2021Article
- Impacts of Small RNAs and Their Chaperones on Bacterial Pathogenicity.Frontiers in cellular and infection microbiology · 2021Review
- Regulation of OmpA Translation and Shigella dysenteriae Virulence by an RNA Thermometer.Infection and immunity · 2020Article
- A small RNA controls bacterial sensitivity to gentamicin during iron starvation.PLoS genetics · 2019Article
- Detection and Categorization of Diarrheagenic Escherichia coli with Auto-microfluidic Thin-film Chip Method.Scientific reports · 2018Article
- Bacterial Iron Homeostasis Regulation by sRNAs.Microbiology spectrum · 2018Review
- RNA-based mechanisms of virulence control in Enterobacteriaceae.RNA biology · 2017Review
- Article
- Transcriptomic analysis of staphylococcal sRNAs: insights into species-specific adaption and the evolution of pathogenesis.Microbial genomics · 2016Article
- Virulence Gene Profile and Multilocus Variable-Number Tandem-Repeat Analysis (MLVA) of Enteroinvasive Escherichia coli (EIEC) Isolates From Patients With Diarrhea in Kerman, Iran.Jundishapur journal of microbiology · 2016Article
- Riboregulators: Fine-Tuning Virulence in Shigella.Frontiers in cellular and infection microbiology · 2016Review
- Role of intracellular carbon metabolism pathways in Shigella flexneri virulence.Infection and immunity · 2014Article
- Small-molecule inhibitor of the Shigella flexneri master virulence regulator VirF.Infection and immunity · 2013Article
- Characterization of the ospZ promoter in Shigella flexneri and its regulation by VirB and H-NS.Journal of bacteriology · 2013Article
- Iron-responsive bacterial small RNAs: variations on a theme.Metallomics : integrated biometal science · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Infection of the human host by Shigella species requires the coordinated production of specific Shigella virulence factors, a process mediated largely by the VirF/VirB regulatory cascade. VirF promotes the transcription of virB, a gene encoding the transcriptional activator of several virulence-associated genes. This study reveals that transcription of virB is also regulated by the small RNA RyhB, and importantly, that this regulation is not achieved indirectly via modulation of VirF activity. These data are the first to demonstrate that the regulation of virB transcription can be uncoupled from the master regulator VirF. It is also established that efficient RyhB-dependent regulation of transcription is facilitated by specific nucleic acid sequences within virB. This study not only reveals RyhB-dependent regulation of virB transcription as a novel point of control in the central regulatory circuit modulating Shigella virulence, but also highlights the versatility of RyhB in controlling bacterial gene expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.