Evidence map›Paper›PMID 22701664›Full record

ArticlePloS one2012

Factors associated with the performance of a blood-based interferon-γ release assay in diagnosing tuberculosis.

Sally Banfield, Elaine Pascoe, Aesen Thambiran, Aris Siafarikas, David Burgner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  18. Effect of DOTS Treatment on Vitamin D Levels in Pulmonary Tuberculosis.Journal of clinical and diagnostic research : JCDR · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sally BanfieldSchool of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.
Elaine Pascoe
Aesen Thambiran
Aris Siafarikas
David Burgner
University of Western Australia · AUPrincess Margaret Hospital for Children · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndeterminate results are a recognised limitation of interferon-γ release assays (IGRA) in the diagnosis of latent tuberculosis (TB) infection (LTBI) and TB disease, especially in children. We investigated whether age and common co-morbidities were associated with IGRA performance in an unselected cohort of resettled refugees.

methodsA retrospective cross-sectional study of refugees presenting for their post-resettlement health assessment during 2006 and 2007. Refugees were investigated for prevalent infectious diseases, including TB, and for common nutritional deficiencies and haematological abnormalities as part of standard clinical screening protocols. Tuberculosis screening was performed by IGRA; QuantiFERON-TB Gold in 2006 and QuantiFERON-TBGold In-Tube in 2007.

resultsComplete data were available on 1130 refugees, of whom 573 (51%) were children less than 17 years and 1041 (92%) were from sub-Saharan Africa. All individuals were HIV negative. A definitive IGRA result was obtained in 1004 (89%) refugees, 264 (26%) of which were positive; 256 (97%) had LTBI and 8 (3%) had TB disease. An indeterminate IGRA result was obtained in 126 (11%) refugees (all failed positive mitogen control). In multivariate analysis, younger age (linear OR= 0.93 [95% CI 0.91-0.95], P<0.001), iron deficiency anaemia (2.69 [1.51-4.80], P = 0.001), malaria infection (3.04 [1.51-6.09], P = 0.002), and helminth infection (2.26 [1.48-3.46], P<0.001), but not vitamin D deficiency or insufficiency, were associated with an indeterminate IGRA result.

conclusionsYounger age and a number of common co-morbidities are significantly and independently associated with indeterminate IGRA results in resettled predominantly African refugees.

Indexed as

AdolescentAdultAfrica South of the SaharaAge FactorsAnemiaChildChild, PreschoolCohort StudiesCommunicable DiseasesComorbidityCross-Sectional StudiesFemaleHumansInterferon-gamma Release TestsLatent TuberculosisLogistic Models

Identifiers

PMID22701664
PMCPMC3373489
OpenAlexW2005941807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.