ArticlePloS one2012
Comparative genomics of Helicobacter pylori strains of China associated with different clinical outcome.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Comparative genomic analysis of Helicobacter pylori isolates from gastric cancer and gastritis in China.BMC cancer · 2025Article
- Alterations of Fucosyltransferase Genes and Fucosylated Glycans in Gastric Epithelial Cells Infected withPathogens (Basel, Switzerland) · 2021Article
- Membrane Proteocomplexome ofFrontiers in microbiology · 2020Article
- Integrative and Conjugative Elements ofFrontiers in cellular and infection microbiology · 2020Article
- Complete Genome Sequence of Helicobacter pylori Strain GD63, Isolated from a Vietnamese Patient with a Gastric Ulcer.Microbiology resource announcements · 2019Article
- Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NFκB pathway in gastric cancer development.Oncotarget · 2016Article
- Article
- Pan-genome analysis of human gastric pathogen H. pylori: comparative genomics and pathogenomics approaches to identify regions associated with pathogenicity and prediction of potential core therapeutic targets.BioMed research international · 2015Article
- Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia.Scientific reports · 2014Article
- Genomic characterization of a Helicobacter pylori isolate from a patient with gastric cancer in China.Gut pathogens · 2014Article
- Genome sequences of three Helicobacter pylori strains isolated from atrophic gastritis and gastric ulcer patients in China.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a whole-genome CombiMatrix Custom oligonucleotide tiling microarray with 90,000 probes covering six sequenced Helicobacter pylori (H. pylori) genomes was designed. This microarray was used to compare the genomic profiles of eight unsequenced strains isolated from patients with different gastroduodenal diseases in Heilongjiang province of China. Since significant genomic variation was found among these strains, an additional 76 H. pylori strains associated with different clinical outcomes were isolated from various provinces of China. These strains were tested by polymerase chain reaction to demonstrate this distinction. We identified several highly variable regions in strains associated with gastritis, gastric ulceration, and gastric cancer. These regions are associated with genes involved in the bacterial type I, type II, and type III R-M systems. They were also associated with the virB gene, which lies on the well-studied cag pathogenic island. While previous studies have reported on the diverse genetic characterization of this pathogenic island, in this study, we find that it is conserved in all strains tested by microarray. Moreover, a number of genes involved in the type IV secretion system, which is related to horizontal DNA transfer between H. pylori strains, were identified in the comparative analysis of the strain-specific genes. These findings may provide insight into new biomarkers for the prediction of gastric diseases.
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