ArticlePloS one2012
Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 82 citations in OpenAlex.
- Postnatal development of the epididymis from birth until puberty of indigenous sheep (Barind-type) in Bangladesh.Journal of advanced veterinary and animal research · 2025Article
- Sperm-borne small non-coding RNAs: potential functions and mechanisms as epigenetic carriers.Cell & bioscience · 2025Review
- Staining patterns of PNA and UEA-I lectins in the postnatal developing male genital excurrent duct epithelium in mice.Journal of advanced veterinary and animal research · 2024Article
- Unlocking Genetic Mysteries during the Epic Sperm Journey toward Fertilization: Further ExpandingBiomolecules · 2024Review
- RUNX transcription factors are essential in maintaining epididymal epithelial differentiation.Cellular and molecular life sciences : CMLS · 2024Article
- Epithelial and mesenchymal fate decisions in Wolffian duct development.Trends in endocrinology and metabolism: TEM · 2023Review
- Vasopressin V1a receptor and oxytocin receptor regulate murine sperm motility differently.Life science alliance · 2023Article
- Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse.eLife · 2023Article
- Alpha/Beta Hydrolase Domain-Containing Protein 2 Regulates the Rhythm of Follicular Maturation and Estrous Stages of the Female Reproductive Cycle.Frontiers in cell and developmental biology · 2021Article
- A novel mouse line with epididymal initial segment-specific expression of Cre recombinase driven by the endogenous Lcn9 promoter.PloS one · 2021Article
- Article
- Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality.Journal of clinical medicine · 2020Review
- Differential expression and localisation of TGF-β isoforms and receptors in the murine epididymis.Scientific reports · 2020Article
- From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential.Frontiers in cell and developmental biology · 2020Review
- Sperm-borne miR-216b modulates cell proliferation during early embryo development via K-RAS.Scientific reports · 2019Article
- DICER1 regulates antibacterial function of epididymis by modulating transcription of β-defensins.Journal of molecular cell biology · 2019Article
- MicroRNAs: Recent insights towards their role in male infertility and reproductive cancers.Bosnian journal of basic medical sciences · 2019Review
- Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4.Scientific reports · 2018Article
- Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm.Developmental cell · 2018Article
- Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse.American journal of human genetics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe postnatal development of the epididymis is a complex process that results in a highly differentiated epithelium, divided into several segments. Recent studies indicate a role for RNA interference (RNAi) in the development of the epididymis, however, the actual requirement for RNAi has remained elusive. Here, we present the first evidence of a direct need for RNAi in the differentiation of the epididymal epithelium. METHODOLOGY/PRINCIPAL
findingsBy utilizing the Cre-LoxP system we have generated a conditional knock-out of Dicer1 in the two most proximal segments of the mouse epididymis. Recombination of Dicer1, catalyzed by Defb41(iCre/wt), took place before puberty, starting from 12 days postpartum. Shortly thereafter, downregulation of the expression of two genes specific for the most proximal epididymis (lipocalin 8 and cystatin 8) was observed. Following this, segment development continued until week 5 at which age the epithelium started to regress back to an undifferentiated state. The dedifferentiated epithelium also showed an increase in estrogen receptor 1 expression while the expression of androgen receptor and its target genes; glutathione peroxidase 5, lipocalin 5 and cysteine-rich secretory protein 1 was downregulated, indicating imbalanced sex steroid signaling. CONCLUSIONS/SIGNIFICANCE: At the time of the final epididymal development, Dicer1 acts as a regulator of signaling pathways essential for maintaining epithelial cell differentiation.
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