ArticlePloS one2012
Sex differences and autism: brain function during verbal fluency and mental rotation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Sex/gender differences in the human autistic brains: A systematic review of 20 years of neuroimaging research.NeuroImage. Clinical · 2021Pooled it
- Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings.NeuroImage. Clinical · 2021Pooled it
- Patterns of Nonsocial and Social Cognitive Functioning in Adults With Autism Spectrum Disorder: A Systematic Review and Meta-analysis.JAMA psychiatry · 2019Pooled it
- Visuo-spatial performance in autism: a meta-analysis.Journal of autism and developmental disorders · 2014Pooled it
- The "Reading the Mind in the Eyes" Test: Complete Absence of Typical Sex Difference in ~400 Men and Women with Autism.PloS one · 2015Trial
- Using Organoids to Model Sex Differences in the Human Brain.Biological psychiatry global open science · 2024Review
- Increased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder.Research in autism spectrum disorders · 2022Article
- Intact fluency in autism? A comprehensive approach of verbal fluency task including word imageability and concreteness.Autism research : official journal of the International Society for Autism Research · 2022Article
- Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response.BMC psychiatry · 2022Article
- Aberrant prefrontal functional connectivity during verbal fluency test is associated with reading comprehension deficits in autism spectrum disorder: An fNIRS study.Frontiers in psychology · 2022Article
- Sex Differences in Salience Network Connectivity and its Relationship to Sensory Over-Responsivity in Youth with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Sex Differences in Functional Connectivity of the Salience, Default Mode, and Central Executive Networks in Youth with ASD.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Neural self-representation in autistic women and association with 'compensatory camouflaging'.Autism : the international journal of research and practice · 2019Article
- Women and Autism Spectrum Disorder: Diagnosis and Implications for Treatment of Adolescents and Adults.Current psychiatry reports · 2019Review
- Testing the Empathizing-Systemizing theory of sex differences and the Extreme Male Brain theory of autism in half a million people.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Sex bias in autism: new insights from Chd8 mutant mice?Nature neuroscience · 2018Article
- Sex Differences in Autism Spectrum Disorder: a Review.Current psychiatry reports · 2018Review
- The Shepard Illusion Is Reduced in Children With an Autism Spectrum Disorder Because of Perceptual Rather Than Attentional Mechanisms.Frontiers in psychology · 2018Article
- In vivo and in vitro sex differences in the dendritic morphology of developing murine hippocampal and cortical neurons.Scientific reports · 2017Article
- Emotion Perception Mediates the Predictive Relationship Between Verbal Ability and Functional Outcome in High-Functioning Adults with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
Autism spectrum conditions (ASC) affect more males than females. This suggests that the neurobiology of autism: 1) may overlap with mechanisms underlying typical sex-differentiation or 2) alternately reflect sex-specificity in how autism is expressed in males and females. Here we used functional magnetic resonance imaging (fMRI) to test these alternate hypotheses. Fifteen men and fourteen women with Asperger syndrome (AS), and sixteen typically developing men and sixteen typically developing women underwent fMRI during performance of mental rotation and verbal fluency tasks. All groups performed the tasks equally well. On the verbal fluency task, despite equivalent task-performance, both males and females with AS showed enhanced activation of left occipitoparietal and inferior prefrontal activity compared to controls. During mental rotation, there was a significant diagnosis-by-sex interaction across occipital, temporal, parietal, middle frontal regions, with greater activation in AS males and typical females compared to AS females and typical males. These findings suggest a complex relationship between autism and sex that is differentially expressed in verbal and visuospatial domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.