ArticlePloS one2012
The ROS scavenger, NAC, regulates hepatic Vα14iNKT cells signaling during Fas mAb-dependent fulminant liver failure.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
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- S100A9 Derived from Chemoembolization-Induced Hypoxia Governs Mitochondrial Function in Hepatocellular Carcinoma Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers.Frontiers in immunology · 2022Article
- Fructose Induces Pulmonary Fibrotic Phenotype Through Promoting Epithelial-Mesenchymal Transition Mediated by ROS-Activated Latent TGF-β1.Frontiers in nutrition · 2022Article
- Knockdown of Dual Oxidase 1 (DUOX1) Promotes Wound Healing by Regulating Reactive Oxygen Species (ROS) by Activation of Nuclear Kactor kappa B (NF-κB) Signaling.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- MARCH5 overexpression contributes to tumor growth and metastasis and associates with poor survival in breast cancer.Cancer management and research · 2019Article
- Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes.Drug design, development and therapy · 2019Article
- Activation of natural killer T cells contributes to triptolide-induced liver injury in mice.Acta pharmacologica Sinica · 2018Article
- MTP18 overexpression contributes to tumor growth and metastasis and associates with poor survival in hepatocellular carcinoma.Cell death & disease · 2018Article
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- Non-Thermal Atmospheric Pressure Plasma Efficiently Promotes the Proliferation of Adipose Tissue-Derived Stem Cells by Activating NO-Response Pathways.Scientific reports · 2016Article
- Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation.Autophagy · 2016Article
- Intracellular ROS mediates gas plasma-facilitated cellular transfection in 2D and 3D cultures.Scientific reports · 2016Article
- Sublethal vancomycin-induced ROS mediating antibiotic resistance in Staphylococcus aureus.Bioscience reports · 2015Article
- Gambogic Acid lysinate induces apoptosis in breast cancer mcf-7 cells by increasing reactive oxygen species.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice.Disease models & mechanisms · 2014Article
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- Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy.Cardiovascular diabetology · 2013Article
- Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis.Antimicrobial agents and chemotherapy · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Uncontrolled systemic activation of the immune system is an early initiating event that leads to development of acute fulminant liver failure (FLF) in mice after treatment with agonistic Fas mAb. In this study, we demonstrate that treatment of mice with N-acetylcysteine (NAC), an ROS scavenger and glutathione (GSH) precursor, almost completely abolished Fas mAb-induced FLF through suppression of Vα14iNKT cell activation, IFN-γ signaling, apoptosis and nitrotyrosine formation in liver. In addition, enrichment of the liver with GSH due to Vα14iNKT cells deficiency, induced an anti-inflammatory response in the liver of Jα18(-/-) mice that inhibited apoptosis, nitrotyrosine formation, IFN-γ signaling and effector functions. In summary, we propose a novel and previously unrecognized pro-inflammatory and pro-apoptotic role for endogenous ROS in stimulating Th1 signaling in Vα14iNKT cells to promote the development of FLF. Therefore, our study provides critical new insights into how NAC, a ROS scavenger, regulates Th1 signaling in intrahepatic Vα14iNKT cells to impact inflammatory and pathological responses.
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