ArticlePloS one2012
CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review.The European journal of neuroscience · 2022Pooled it
- Imaging Alzheimer's genetic risk using diffusion MRI: A systematic review.NeuroImage. Clinical · 2020Pooled it
- Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer's disease.Human brain mapping · 2018Trial
- Quantitative magnetic resonance imaging in Alzheimer's disease: a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants.Neurobiology of aging · 2024Article
- Correlation of brain tissue volume loss with inflammatory biomarkers IL1β, P-tau, T-tau, and NLPR3 in the aging cognitively impaired population.Frontiers in aging neuroscience · 2024Article
- Layer-specific microstructural patterns of anterior hippocampus in Alzheimer's disease with ex vivo diffusion MRI at 14.1 T.Human brain mapping · 2023Article
- Plasma neurofilament light levels correlate with white matter damage prior to Alzheimer's disease: results from ADNI.Aging clinical and experimental research · 2022Article
- Principal components from untargeted cerebrospinal fluid metabolomics associated with Alzheimer's disease biomarkers.Neurobiology of aging · 2022Article
- White matter microstructure associations to amyloid burden in adults with Down syndrome.NeuroImage. Clinical · 2022Article
- Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players.Journal of magnetic resonance imaging : JMRI · 2021Article
- White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study.Journal of neurodevelopmental disorders · 2021Article
- Diagnosis of Alzheimer's Disease Using Brain Network.Frontiers in neuroscience · 2021Article
- Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease.Brain : a journal of neurology · 2020Article
- Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions.Alzheimer's research & therapy · 2020Article
- Cohort study of electroencephalography markers of amyloid-tau-neurodegeneration pathology.Brain communications · 2020Article
- The role of myelin damage in Alzheimer's disease pathology.Archives of medical science : AMS · 2020Article
- Systems modeling of white matter microstructural abnormalities in Alzheimer's disease.NeuroImage. Clinical · 2020Article
- When Does Alzheimer's Disease Really Start? The Role of Biomarkers.International journal of molecular sciences · 2019Review
- A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Cerebrospinal fluid (CSF) biomarkers T-Tau and Aβ(42) are linked with Alzheimer's disease (AD), yet little is known about the relationship between CSF biomarkers and structural brain alteration in healthy adults. In this study we examined the extent to which AD biomarkers measured in CSF predict brain microstructure indexed by diffusion tensor imaging (DTI) and volume indexed by T1-weighted imaging. Forty-three middle-aged adults with parental family history of AD received baseline lumbar puncture and MRI approximately 3.5 years later. Voxel-wise image analysis methods were used to test whether baseline CSF Aβ(42), total tau (T-Tau), phosphorylated tau (P-Tau) and neurofilament light protein predicted brain microstructure as indexed by DTI and gray matter volume indexed by T1-weighted imaging. T-Tau and T-Tau/Aβ(42) were widely correlated with indices of brain microstructure (mean, axial, and radial diffusivity), notably in white matter regions adjacent to gray matter structures affected in the earliest stages of AD. None of the CSF biomarkers were related to gray matter volume. Elevated P-Tau and P-Tau/Aβ(42) levels were associated with lower recognition performance on the Rey Auditory Verbal Learning Test. Overall, the results suggest that CSF biomarkers are related to brain microstructure in healthy adults with elevated risk of developing AD. Furthermore, the results clearly suggest that early pathological changes in AD can be detected with DTI and occur not only in cortex, but also in white matter.
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Registered trials
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