ArticlePloS one2012
The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03670693 (Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy.Scientific reports · 2016Trial
- Questioning the kidney-protective effects of tolvaptan: a testable hypothesis to revisit the current narrative.Open research Europe · 2025Article
- Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade.Nature communications · 2024Article
- Exploring the links of skeletal muscle mitochondrial oxidative capacity, physical functionality, and mental well-being of cancer survivors.Scientific reports · 2024Article
- Cardiac and intramuscular adaptations following short-term exercise prehabilitation in unfit patients scheduled to undergo hepatic or pancreatic surgery: study protocol of a multinuclear MRI study.BMJ open gastroenterology · 2023Article
- Myocardial Fatigue: a Mechano-energetic Concept in Heart Failure.Current cardiology reports · 2022Review
- Ankle-Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA.Journal of the American Heart Association · 2022Article
- Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.Scientific reports · 2022Article
- Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla.Magnetic resonance in medicine · 2021Article
- Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.Journal of the American Geriatrics Society · 2019Article
- The Role of Muscle Perfusion in the Age-Associated Decline of Mitochondrial Function in Healthy Individuals.Frontiers in physiology · 2019Article
- Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low-Normal Ankle-Brachial Index.Journal of the American Heart Association · 2017Article
- Muscle strength mediates the relationship between mitochondrial energetics and walking performance.Aging cell · 2017Article
- A low-cost Mr compatible ergometer to assess post-exercise phosphocreatine recovery kinetics.Magma (New York, N.Y.) · 2017Article
- 31P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a Predictor of Gait Speed in the Baltimore Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- DynamicNMR in biomedicine · 2016Article
- Repeatability of (31) P MRSI in the human brain at 7 T with and without the nuclear Overhauser effect.NMR in biomedicine · 2016Article
- Muscle torque relative to cross-sectional area and the functional muscle-bone unit in children and adolescents with chronic disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveMagnetic resonance spectroscopy (MRS) provides an exceptional opportunity for the study of in vivo metabolism. MRS is widely used to measure phosphorus metabolites in trained muscle, although there are no published data regarding its reproducibility in this specialized cohort. Thus, the aim of this study was to assess the reproducibility of (31)P-MRS in trained skeletal muscle.
methodsWe recruited fifteen trained men (VO(2)peak = 4.7±0.8 L min(-1)/58±8 mL kg(-1) min(-1)) and performed duplicate MR experiments during plantar flexion exercise, three weeks apart.
resultsMeasures of resting phosphorus metabolites were reproducible, with 1.7 mM the smallest detectable difference in phosphocreatine (PCr). Measures of metabolites during exercise were less reliable: exercising PCr had a coefficient of variation (CV) of 27% during exercise, compared with 8% at rest. Estimates of mitochondrial function were variable, but experimentally useful. The CV of PCr(1/2t) was 40%, yet much of this variance was inter-subject such that differences of <20% were detectable with n = 15, given a significance threshold of p<0.05.
conclusions31-phosphorus MRS provides reproducible and experimentally useful measures of phosphorus metabolites and mitochondrial function in trained human skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.