ArticlePloS one2012
Enhanced transmission of drug-resistant parasites to mosquitoes following drug treatment in rodent malaria.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Malaria parasites can optimize transmission investment by sensing two within-host cues.PLoS biology · 2025Article
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- Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.Parasites & vectors · 2022Review
- Revisiting the Effect of Pharmaceuticals on Transmission Stage Formation in the Malaria ParasiteFrontiers in cellular and infection microbiology · 2022Article
- Gametocyte Carriage, Antimalarial Use, and Drug Resistance in Cambodia, 2008-2014.The American journal of tropical medicine and hygiene · 2018Article
- Adaptive plasticity in the gametocyte conversion rate of malaria parasites.PLoS pathogens · 2018Article
- Within-host competition can delay evolution of drug resistance in malaria.PLoS biology · 2018Article
- Altered life history strategies protect malaria parasites against drugs.Evolutionary applications · 2018Article
- The impact of within-host ecology on the fitness of a drug-resistant parasite.Evolution, medicine, and public health · 2018Article
- Resource limitation prevents the emergence of drug resistance by intensifying within-host competition.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- What is a vector?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Predicting optimal transmission investment in malaria parasites.Evolution; international journal of organic evolution · 2016Article
- Review
- Within-host competition and drug resistance in the human malaria parasite Plasmodium falciparum.Proceedings. Biological sciences · 2016Article
- Adaptive Landscape by Environment Interactions Dictate Evolutionary Dynamics in Models of Drug Resistance.PLoS computational biology · 2016Article
- An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development.Nature protocols · 2015Article
- Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector.PLoS pathogens · 2015Article
- Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi.The American journal of tropical medicine and hygiene · 2015Article
- The effect of intermittent preventive treatment on anti-malarial drug resistance spread in areas with population movement.Malaria journal · 2014Article
- Establishment of macrocyclic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs.Parasites & vectors · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The evolution of drug resistant Plasmodium parasites is a major challenge to effective malaria control. In theory, competitive interactions between sensitive parasites and resistant parasites within infections are a major determinant of the rate at which parasite evolution undermines drug efficacy. Competitive suppression of resistant parasites in untreated hosts slows the spread of resistance; competitive release following treatment enhances it. Here we report that for the murine model Plasmodium chabaudi, co-infection with drug-sensitive parasites can prevent the transmission of initially rare resistant parasites to mosquitoes. Removal of drug-sensitive parasites following chemotherapy enabled resistant parasites to transmit to mosquitoes as successfully as sensitive parasites in the absence of treatment. We also show that the genetic composition of gametocyte populations in host venous blood accurately reflects the genetic composition of gametocytes taken up by mosquitoes. Our data demonstrate that, at least for this mouse model, aggressive chemotherapy leads to very effective transmission of highly resistant parasites that are present in an infection, the very parasites which undermine the long term efficacy of front-line drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.