ArticlePloS one2012
Psychoactive pharmaceuticals induce fish gene expression profiles associated with human idiopathic autism.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 46 citations in OpenAlex.
- Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test.International journal of environmental research and public health · 2021Article
- The potential association of psychoactive pharmaceuticals in the environment with human neurological disorders.Sustainable chemistry and pharmacy · 2019Article
- Contamination profiles, mass loadings, and sewage epidemiology of neuropsychiatric and illicit drugs in wastewater and river waters from a community in the Midwestern United States.The Science of the total environment · 2018Article
- Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations.Neuroscience letters · 2017Article
- Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders.BMC genomics · 2016Article
- Maternal exposure to carbamazepine at environmental concentrations can cross intestinal and placental barriers.Biochemical and biophysical research communications · 2016Article
- Psychoactive pharmaceuticals as environmental contaminants may disrupt highly inter-connected nodes in an Autism-associated protein-protein interaction network.BMC bioinformatics · 2015Article
- Leveraging existing data for prioritization of the ecological risks of human and veterinary pharmaceuticals to aquatic organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- An ecological study on childhood autism.International journal of health geographics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Idiopathic autism, caused by genetic susceptibility interacting with unknown environmental triggers, has increased dramatically in the past 25 years. Identifying environmental triggers has been difficult due to poorly understood pathophysiology and subjective definitions of autism. The use of antidepressants by pregnant women has been associated with autism. These and other unmetabolized psychoactive pharmaceuticals (UPPs) have also been found in drinking water from surface sources, providing another possible exposure route and raising questions about human health consequences. Here, we examined gene expression patterns of fathead minnows treated with a mixture of three psychoactive pharmaceuticals (fluoxetine, venlafaxine & carbamazepine) in dosages intended to be similar to the highest observed conservative estimates of environmental concentrations. We conducted microarray experiments examining brain tissue of fish exposed to individual pharmaceuticals and a mixture of all three. We used gene-class analysis to test for enrichment of gene sets involved with ten human neurological disorders. Only sets associated with idiopathic autism were unambiguously enriched. We found that UPPs induce autism-like gene expression patterns in fish. Our findings suggest a new potential trigger for idiopathic autism in genetically susceptible individuals involving an overlooked source of environmental contamination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.