ArticleEvidence-based complementary and alternative medicine : eCAM2012
Anti-hepatitis B virus effect and possible mechanism of action of 3,4-o-dicaffeoylquinic Acid in vitro and in vivo.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Design and Evaluation of Novel HIV-1 Protease Inhibitors Containing Phenols or Polyphenols as P2 Ligands with High Activity against DRV-Resistant HIV-1 Variants.International journal of molecular sciences · 2022Article
- Article
- Drug Design Strategies for the Treatment of Viral Disease. Plant Phenolic Compounds and Their Derivatives.Frontiers in pharmacology · 2021Review
- Hepatoprotective and Antioxidant Capacity ofACS omega · 2020Article
- In vitro inhibition effects of hepatitis B virus by dandelion and taraxasterol.Infectious agents and cancer · 2020Article
- Ginsenoside Rg1 attenuates liver injury induced by D-galactose in mice.Experimental and therapeutic medicine · 2018Article
- Novel caffeoylquinic acid derivatives fromRSC advances · 2018Article
- Naturally derived anti-hepatitis B virus agents and their mechanism of action.World journal of gastroenterology · 2016Review
- Hepatoprotective effects of Micromeria croatica ethanolic extract against CCl4-induced liver injury in mice.BMC complementary and alternative medicine · 2015Article
- In silico analysis and experimental validation of active compounds from fructus Schisandrae chinensis in protection from hepatic injury.Cell proliferation · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-hepatitis B activity of 3,4-O-dicaffeoylquinic acid isolated from Laggera alata was studied using the D-galactosamine- (D-GalN-) induced hepatocyte damage model, HepG2.2.15 cells, and with HBV transgenic mice. In vitro results showed that 3,4-O-dicaffeoylquinic acid improved HL-7702 hepatocyte viability and markedly inhibited the production of HBsAg and HBeAg. At a concentration of 100 μg/mL, its inhibitory rates on the expression levels of HBsAg and HBeAg were 89.96% and 81.01%, respectively. The content of hepatitis B virus covalently closed circular DNA (HBV cccDNA) in HepG2.2.15 cells was significantly decreased after the cells were treated with the test compound. In addition, 3,4-O-dicaffeoylquinic acid significantly increased the expression of heme oxygenase-1 (HO-1) in HepG2.2.15 cells. In vivo results indicated that the test compound at concentrations of 100 μg/mL significantly inhibited HBsAg production and increased HO-1 expression in HBV transgenic mice. In conclusion, this study verifies the anti-hepatitis B activity of 3,4-O-dicaffeoylquinic acid. The upregulation of HO-1 may contribute to the anti-HBV effect of this compound by reducing the stability of the HBV core protein, which blocks the refill of nuclear HBV cccDNA. Furthermore, the hepatoprotective effect of this compound may be mediated through its antioxidative/anti-inflammatory properties and by the induction of HO-1 expression.
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Registered trials
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