ArticleCurrent gerontology and geriatrics research2012
Alzheimer's disease promotion by obesity: induced mechanisms-molecular links and perspectives.
Article in Current gerontology and geriatrics research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Therapeutic Potential of Leptin in Neurodegenerative Disease.Biomedicines · 2025Review
- Adipokines at the Metabolic-Brain Interface: Therapeutic Modulation by Antidiabetic Agents and Natural Compounds in Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases.Current issues in molecular biology · 2024Review
- Epigenetics as a link between environmental factors and dementia risk.Journal of Alzheimer's disease reports · 2024Review
- Ghrelin system in Alzheimer's disease.Current opinion in neurobiology · 2023Review
- Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline.International journal of molecular sciences · 2022Review
- Plasma Leptin Reflects Progression of Neurofibrillary Pathology in Animal Model of Tauopathy.Cellular and molecular neurobiology · 2022Article
- Nutrients, Cognitive Function, and Brain Aging: What We Have Learned from Dogs.Medical sciences (Basel, Switzerland) · 2021Review
- Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms.AIMS neuroscience · 2021Review
- Women who breastfeed exhibit cognitive benefits after age 50.Evolution, medicine, and public health · 2021Article
- Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview.Frontiers in neuroscience · 2020Review
- Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer's Dementia.Frontiers in physiology · 2020Review
- Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells.World journal of stem cells · 2019Review
- Leptin Regulation of Synaptic Function at Hippocampal TA-CA1 and SC-CA1 Synapses: Implications for Health and Disease.Neurochemical research · 2019Review
- Associations between obesity and cognitive impairment in the Chinese elderly: an observational study.Clinical interventions in aging · 2019Observational
- High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss.Neurobiology of learning and memory · 2019Article
- Microbiome-metabolome signatures in mice genetically prone to develop dementia, fed a normal or fatty diet.Scientific reports · 2018Article
- Biomarkers for cognitive decline in patients with diabetes mellitus: evidence from clinical studies.Oncotarget · 2018Article
- Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders ≥65 Years.Journal of Alzheimer's disease : JAD · 2018Article
- Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration ofJournal of veterinary science · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of AD is increasing in parallel with the increase in life expectancy. At the same time the prevalence of metabolic syndrome and obesity is reaching epidemic proportions in western populations. Stress is one of the major inducers of visceral fat and obesity development, underlying accelerated aging processes. Adipose tissue is at present considered as an active endocrine organ, producing important mediators involved in metabolism regulation as well as in inflammatory mechanisms. Insulin and leptin resistance has been related to the dysregulation of energy balance and to the induction of a chronic inflammatory status which have been recognized as important cofactors in cognitive impairment and AD initiation and progression. The aim of this paper is to disclose the correlation between the onset and progression of AD and the stress-induced changes in lifestyle, leading to overnutrition and reduced physical activity, ending with metabolic syndrome and obesity. The involved molecular mechanisms will be briefly discussed, and advisable guide lines for the prevention of AD through lifestyle modifications will be proposed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.