ArticleTheScientificWorldJournal2012
Properties and biocompatibility of chitosan and silk fibroin blend films for application in skin tissue engineering.
Article in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Sustained insulin-delivery as a growth factor for modulating oral mucosa healing: A case series.Archives of oral biology · 2026Article
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- Article
- Freeze-Dried Chitosan Scaffolds Containing Grape Seed Oil for Wound Healing Applications.ACS omega · 2025Article
- Biodegradable Silk Fibroin Matrices for Wound Closure in a Human 3D Ex Vivo Approach.Materials (Basel, Switzerland) · 2024Article
- 3D-bioprinted GelMA/gelatin/amniotic membrane extract (AME) scaffold loaded with keratinocytes, fibroblasts, and endothelial cells for skin tissue engineering.Scientific reports · 2024Article
- A comprehensive review on recent advances in preparation, physicochemical characterization, and bioengineering applications of biopolymers.Polymer bulletin (Berlin, Germany) · 2023Review
- Human epidermal keratinocytes and human dermal fibroblasts interactions seeded on gelatin hydrogel for future application in skinFrontiers in bioengineering and biotechnology · 2023Article
- Article
- Review
- Review
- A Comparative Analysis of the Structure and Biological Properties of Films and Microfibrous Scaffolds Based on Silk Fibroin.Pharmaceutics · 2021Article
- Fabrication and characterization of an antibacterial chitosan/silk fibroin electrospun nanofiber loaded with a cationic peptide for wound-dressing application.Journal of materials science. Materials in medicine · 2021Article
- Biomaterials for Skin Substitutes.Advanced healthcare materials · 2018Review
- Carbohydrates-chitosan composite carrier for Vero cell culture.Cytotechnology · 2016Article
- Silk-PVA Hybrid Nanofibrous Scaffolds for Enhanced Primary Human Meniscal Cell Proliferation.The Journal of membrane biology · 2016Article
- Compatibility of Porous Chitosan Scaffold with the Attachment and Proliferation of human Adipose-Derived Stem CellsJournal of stem cells & regenerative medicine · 2016Article
- Past, present, and future of microcarrier-based tissue engineering.Journal of orthopaedic translation · 2015Review
- Biobased silver nanocolloid coating on silk fibers for prevention of post-surgical wound infections.International journal of nanomedicine · 2015Article
- Contribution of fibroblasts to the mechanical stability of in vitro engineered dermal-like tissue through extracellular matrix deposition.BioResearch open access · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chitosan/silk fibroin (CS/SF) blend films were prepared and evaluated for feasibility of using the films as biomaterial for skin tissue engineering application. Fourier transform infrared spectroscopy and differential scanning calorimetry analysis indicated chemical interaction between chitosan and fibroin. Chitosan enhanced β-sheet conformation of fibroin and resulted in shifting of thermal degradation of the films. Flexibility, swelling index, and enzyme degradation were also increased by the chitosan content of the blend films. Biocompatibility of the blend films was determined by cultivation with fibroblast cells. All films showed no cytotoxicity by XTT assay. Fibroblast cells spread on CS/SF films via dendritic extensions, and cell-cell interactions were noted. Cell proliferation on CS/SF films was also demonstrated, and their phenotype was examined by the expression of collagen type I gene. These results showed possibility of using the CS/SF films as a supporting material for further study on skin tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.