ArticleGene regulation and systems biology2012
Binding Motifs in Bacterial Gene Promoters Modulate Transcriptional Effects of Global Regulators CRP and ArcA.
Article in Gene regulation and systems biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- A nitrite-responsive regulatory RNA locus sustains commensal resilience against nitrosative stress.bioRxiv : the preprint server for biology · 2026Article
- High-affinity promotor binding of YhaJ mediates a low signal leakage for effective DNT detection.Frontiers in microbiology · 2024Article
- Determination and Dissection of DNA-Binding Specificity for theInternational journal of molecular sciences · 2020Article
- Enantioselective regulation of lactate racemization by LarR in Lactobacillus plantarum.Journal of bacteriology · 2015Article
- Hierarchy of non-glucose sugars in Escherichia coli.BMC systems biology · 2014Article
- Adaptation to environmental factors shapes the organization of regulatory regions in microbial communities.BMC genomics · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial gene regulation involves transcription factors (TF) that bind to DNA recognition sequences in operon promoters. These recognition sequences, many of which are palindromic, are known as regulatory elements or transcription factor binding sites (TFBS). Some TFs are global regulators that can modulate the expression of hundreds of genes. In this study we examine global regulator half-sites, where a half-site, which we shall call a binding motif (BM), is one half of a palindromic TFBS. We explore the hypothesis that the number of BMs plays an important role in transcriptional regulation, examining empirical data from transcriptional profiling of the CRP and ArcA regulons. We compare the power of BM counts and of full TFBS characteristics to predict induced transcriptional activity. We find that CRP BM counts have a nonlinear effect on CRP-dependent transcriptional activity and predict this activity better than full TFBS quality or location.
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Registered trials
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