ArticleMediators of inflammation2012
Guilty molecules, guilty minds? The conflicting roles of the innate immune response to traumatic brain injury.
Article in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Repeated head impacts establish a senescent cranial bone marrow niche that impairs brain metabolism.Journal of neuroinflammation · 2026Article
- Repeated Mild Head Injury Establishes a Senescent Cranial Bone Marrow Niche that Impairs Brain Metabolism.bioRxiv : the preprint server for biology · 2026Article
- Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/MERTK signaling following brain injury.Journal of neuroinflammation · 2023Article
- Insights into nervous system repair from the fruit fly.Neuronal signaling · 2022Review
- Recent Advances in Stem Cell Therapies to Address Neuroinflammation, Stem Cell Survival, and the Need for Rehabilitative Therapies to Treat Traumatic Brain Injuries.International journal of molecular sciences · 2021Review
- Intrathecal complement activation by the classical pathway in tick-borne encephalitis.Journal of neurovirology · 2019Article
- Minocycline plus N-acteylcysteine induces remyelination, synergistically protects oligodendrocytes and modifies neuroinflammation in a rat model of mild traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- RANTES levels in peripheral blood, CSF and contused brain tissue as a marker for outcome in traumatic brain injury (TBI) patients.BMC research notes · 2017Article
- Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila.G3 (Bethesda, Md.) · 2016Article
- Charting a course for erythropoietin in traumatic brain injury.Journal of translational science · 2016Article
- The association between the Th-17 immune response and pulmonary complications in a trauma ICU population.Cytokine · 2015Article
- Repetitive hyperbaric oxygenation attenuates reactive astrogliosis and suppresses expression of inflammatory mediators in the rat model of brain injury.Mediators of inflammation · 2015Article
- Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia.Investigative ophthalmology & visual science · 2014Article
- Bridge between neuroimmunity and traumatic brain injury.Current pharmaceutical design · 2014Review
- A Drosophila model of closed head traumatic brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Review
- Transcriptome characterization by RNA-Seq reveals the involvement of the complement components in noise-traumatized rat cochleae.Neuroscience · 2013Article
- Wnt your brain be inflamed? Yes, it Wnt!Trends in molecular medicine · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traumatic brain injury (TBI) is a complex disease in the most complex organ of the body, whose victims endure lifelong debilitating physical, emotional, and psychosocial consequences. Despite advances in clinical care, there is no effective neuroprotective therapy for TBI, with almost every compound showing promise experimentally having disappointing results in the clinic. The complex and highly interrelated innate immune responses govern both the beneficial and deleterious molecular consequences of TBI and are present as an attractive therapeutic target. This paper discusses the positive, negative, and often conflicting roles of the innate immune response to TBI in both an experimental and clinical settings and highlights recent advances in the search for therapeutic candidates for the treatment of TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.