ArticleCardiology research and practice2012
The additive effects of type-2 diabetes on cognitive function in older adults with heart failure.
Article in Cardiology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Cognitive impairment in heart transplantation: prevalence, trajectories, and prognostic impact - a systematic review.Aging clinical and experimental research · 2026Pooled it
- Pooled it
- Effect of Exercise on the Cognitive Function of Older Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Frontiers in human neuroscience · 2022Pooled it
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Diabetes mellitus and neurocognition: A report from the Childhood Cancer Survivor Study.Cancer · 2025Article
- Preliminary report: Reduced hand sensory and motor function in persons living with heart failure.PloS one · 2024Article
- Cognitive Dysfunction in Heart Failure: Pathophysiology and Implications for Patient Management.Current heart failure reports · 2022Review
- Exercise Improves Cognitive Function-A Randomized Trial on the Effects of Physical Activity on Cognition in Type 2 Diabetes Patients.Journal of personalized medicine · 2021Article
- The relationship between serum uric acid and cognitive function in patients with chronic heart failure.BMC cardiovascular disorders · 2020Article
- Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders.Journal of molecular medicine (Berlin, Germany) · 2019Review
- What is your patient's cognitive profile? Three distinct subgroups of cognitive function in persons with heart failure.Applied nursing research : ANR · 2015Article
- Higher BMI is associated with reduced brain volume in heart failure.BMC obesity · 2014Article
- Obesity as a risk factor for poor neurocognitive outcomes in older adults with heart failure.Heart failure reviews · 2014Review
- Better adherence to treatment recommendations in heart failure predicts improved cognitive function at a one-year follow-up.Journal of clinical and experimental neuropsychology · 2014Article
- Cognitive performance in older adults with stable heart failure: longitudinal evidence for stability and improvement.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2014Article
- Risk factors for cognitive dysfunction in CKD and hypertensive subjects.International urology and nephrology · 2013Article
- Depressive symptomatology, exercise adherence, and fitness are associated with reduced cognitive performance in heart failure.Journal of aging and health · 2013Article
- The adverse impact of type 2 diabetes on brain volume in heart failure.Journal of clinical and experimental neuropsychology · 2013Article
- Obesity interacts with cerebral hypoperfusion to exacerbate cognitive impairment in older adults with heart failure.Cerebrovascular diseases extra · 2012Article
- Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure.Congestive heart failure (Greenwich, Conn.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
Background. Medical comorbidity has been theorized to contribute to cognitive impairment in heart failure (HF) patients. Specifically, type-2 diabetes mellitus (T2DM), a common coexisting condition among HF patients, may be an independent predictor of cognitive impairment. Nonetheless, the relationships between T2DM and other risk factors for cognitive impairment among persons with HF are unclear. Methods. Persons with HF (N = 169, 34.3% women, age 68.57 ± 10.28 years) completed neuropsychological testing within a framework of an ongoing study. History of T2DM, along with other medical characteristics, was ascertained through a review of participants' medical charts and self-report. Results. Many participants (34.9%) had a comorbid T2DM diagnosis. After adjustment for demographic and medical characteristics, HF patients with T2DM evidenced significantly greater impairments across multiple cognitive domains than HF patients without T2DM: λ = .92, F(5, 156) = 2.82, P = .018. Post hoc tests revealed significant associations between T2DM and attention (P = .003), executive function (P = .032), and motor functioning (P = .008). Conclusion. The findings suggest additive contributions of T2DM and HF to impairments in attention, executive function, and motor function. Future work is needed to elucidate the mechanisms by which T2DM exacerbates cognitive impairment in HF.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.