ArticleFrontiers in psychology2012
Social brain development in williams syndrome: the current status and directions for future research.
Article in Frontiers in psychology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Autistic Traits, Pragmatic Difficulties, and Adaptive Outcomes in Williams Syndrome: A Systematic Narrative Review.Children (Basel, Switzerland) · 2026Review
- Anxiety, concerns and emotion regulation in individuals with Williams syndrome and Down syndrome during the COVID-19 outbreak: a global study.Scientific reports · 2023Article
- Autism and Williams syndrome: truly mirror conditions in the socio-cognitive domain?International journal of developmental disabilities · 2022Review
- From Hyposociability to Hypersociability-The Effects of PSD-95 Deficiency on the Dysfunctional Development of Social Behavior.Frontiers in behavioral neuroscience · 2021Article
- Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.Molecular autism · 2020Article
- Williams Syndrome, Human Self-Domestication, and Language Evolution.Frontiers in psychology · 2019Article
- Attention Bias to Emotional Faces Varies by IQ and Anxiety in Williams Syndrome.Journal of autism and developmental disorders · 2016Article
- Sex differences in amygdala shape: Insights from Turner syndrome.Human brain mapping · 2016Article
- Morphological differences in the mirror neuron system in Williams syndrome.Social neuroscience · 2016Article
- Autonomic response to approachability characteristics, approach behavior, and social functioning in Williams syndrome.Neuropsychologia · 2015Article
- Patterns of Sensitivity to Emotion in Children with Williams Syndrome and Autism: Relations Between Autonomic Nervous System Reactivity and Social Functioning.Journal of autism and developmental disorders · 2015Article
- Relations between social-perceptual ability in multi- and unisensory contexts, autonomic reactivity, and social functioning in individuals with Williams syndrome.Neuropsychologia · 2015Article
- Oxytocin, vasopressin, and Williams syndrome: epigenetic effects on abnormal social behavior.Frontiers in genetics · 2015Article
- Characterizing associations and dissociations between anxiety, social, and cognitive phenotypes of Williams syndrome.Research in developmental disabilities · 2014Article
- Altered microstructure within social-cognitive brain networks during childhood in Williams syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Regionally specific increased volume of the amygdala in Williams syndrome: evidence from surface-based modeling.Human brain mapping · 2014Article
- The social phenotype of Williams syndrome.Current opinion in neurobiology · 2013Review
- What does Williams syndrome reveal about the determinants of social behavior?Frontiers in human neuroscience · 2013Article
- Innovative approaches to the study of social phenotypes in neurodevelopmental disorders: an introduction to the research topic.Frontiers in psychology · 2013Article
- Tracking the Cognitive, Social, and Neuroanatomical Profile in Early Neurodegeneration: Type III Cockayne Syndrome.Frontiers in aging neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Williams syndrome (WS) is a neurodevelopmental condition that occurs as a result of a contiguous deletion of ∼26-28 genes on chromosome 7q11.23. WS is often associated with a distinctive social phenotype characterized by an increased affinity toward processing faces, reduced sensitivity to fear related social stimuli and a reduced ability to form concrete social relationships. Understanding the biological mechanisms that underlie the social phenotype in WS may elucidate genetic and neural factors influencing the typical development of the social brain. In this article, we review available studies investigating the social phenotype of WS throughout development and neuroimaging studies investigating brain structure and function as related to social and emotional functioning in this condition. This review makes an important contribution by highlighting several neuro-behavioral mechanisms that may be a cause or a consequence of atypical social development in WS. In particular, we discuss how distinctive social behaviors in WS may be associated with alterations or delays in the cortical representation of faces, connectivity within the ventral stream, structure and function of the amygdala and how long- and short-range connections develop within the brain. We integrate research on typical brain development and from existing behavioral and neuroimaging research on WS. We conclude with a discussion of how genetic and environmental factors might interact to influence social brain development in WS and how future neuroimaging and behavioral research can further elucidate social brain development in WS. Lastly, we describe how ongoing studies may translate to improved social developmental outcomes for individuals with WS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.