ReviewThe Journal of biological chemistry2012
Circular proteins from plants and fungi.
Review in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Molecular insights into anti-cancer cyclotides and their interaction with breast cancer targets: an in silico study.Molecular diversity · 2026Article
- Advances in cyclotide research: bioactivity to cyclotide-based therapeutics.Molecular diversity · 2025Review
- Enzyme-free biochemical production of seamlessly N-to-C cyclized peptides from natural or recombinant proteins.bioRxiv : the preprint server for biology · 2025Article
- Enzyme-free biochemical production of seamlessly N-to-C cyclized peptides from natural or recombinant proteins.Methods in enzymology · 2025Article
- Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro.Pharmaceutics · 2023Article
- Peptide Toxins as Biothreats and the Potential for AI Systems to Enhance Biosecurity.Frontiers in bioengineering and biotechnology · 2022Article
- Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides.RSC chemical biology · 2021Article
- Cyclotides from BrazilianJournal of natural products · 2021Article
- "Protein" no longer means what it used to.Current research in structural biology · 2021Review
- Article
- Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herbThe Journal of biological chemistry · 2020Article
- Plant Antimicrobial Peptides: State of the Art, In Silico Prediction and Perspectives in the Omics Era.Bioinformatics and biology insights · 2020Review
- Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Bioinspired Designs, Molecular Premise and Tools for Evaluating the Ecological Importance of Antimicrobial Peptides.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta.Journal of experimental botany · 2018Article
- Improved method for quantitative analysis of the cyclotide kalata B1 in plasma and brain homogenate.Biopolymers · 2016Article
- Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae.Frontiers in plant science · 2015Article
- The chemistry and biology of theta defensins.Angewandte Chemie (International ed. in English) · 2014Review
- Article
- Secretion of circular proteins using sortase.Methods in molecular biology (Clifton, N.J.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular proteins, defined as head-to-tail cyclized polypeptides originating from ribosomal synthesis, represent a novel class of natural products attracting increasing interest. From a scientific point of view, these compounds raise questions of where and why they occur in nature and how they are formed. From a rational point of view, these proteins and their structural concept may be exploited for crop protection and novel pharmaceuticals. Here, we review the current knowledge of three protein families: cyclotides and circular sunflower trypsin inhibitors from the kingdom of plants and the Amanita toxins from fungi. A particular emphasis is placed on their biological origin, structure, and activity. In addition, the opportunity for discovery of novel circular proteins and recent insights into their mechanism of action are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.