ArticleAnnals of botany2012
A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses.
Article in Annals of botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 129 citations in OpenAlex.
- Mangiferin as a Polyphenolic Scaffold for Enzyme Targeted Molecular Regulation of Carbohydrate Hydrolyzing Enzymes in Diabetes Management.Applied biochemistry and biotechnology · 2026Article
- Exploring the Dermatological Benefits of Coffee Extracts and Their Derivatives.Antioxidants (Basel, Switzerland) · 2026Review
- Traditional preparation and cultural significance of chemo, an indigenous coffee-leaf beverage in Southwestern Ethiopia.Journal of ethnobiology and ethnomedicine · 2026Article
- Major Bioactive Compounds in Seeds, Husks, and Leaves of Selected Genotypes ofPlants (Basel, Switzerland) · 2025Article
- Major Bioactive Compounds, Volatile and Sensory Profiles ofFoods (Basel, Switzerland) · 2025Article
- Review
- Transcriptome and genome-wide analysis of the mango glycosyltransferase family involved in mangiferin biosynthesis.BMC genomics · 2024Article
- Suppressive Effect of Coffee Leaves on Lipid Digestion and Absorption In Vitro.Foods (Basel, Switzerland) · 2024Article
- Coffee leaf valorisation into functional wheat flour rusk: their nutritional, physicochemical, and sensory properties.Journal of food science and technology · 2024Article
- Metabolic Pathway Reconstruction Indicates the Presence of Important Medicinal Compounds inInternational journal of molecular sciences · 2023Article
- Value-Added Products from Coffee Waste: A Review.Molecules (Basel, Switzerland) · 2023Review
- Xanthones: Biosynthesis and Trafficking in Plants, Fungi and Lichens.Plants (Basel, Switzerland) · 2023Review
- Comparison of chemical compositions, antioxidant activities, and acetylcholinesterase inhibitory activities between coffee flowers and leaves as potential novel foods.Food science & nutrition · 2023Article
- Interactive deciphering electron-shuttling characteristics ofIndustrial crops and products · 2023Article
- Characterization of Extracts of Coffee Leaves (Foods (Basel, Switzerland) · 2022Article
- Targeted and Untargeted Mass Spectrometry-Based Metabolomics for Chemical Profiling of Three Coffee Species.Molecules (Basel, Switzerland) · 2022Article
- Review
- Prospects of Coffee Leaf against SARS-CoV-2 Infection.International journal of biological sciences · 2022Article
- A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry.Frontiers in plant science · 2022Article
- Genetic diversity of wild and cultivated Coffea canephora in northeastern DR Congo and the implications for conservation.American journal of botany · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe phenolic composition of Coffea leaves has barely been studied, and therefore this study conducts the first detailed survey, focusing on mangiferin and hydroxycinnamic acid esters (HCEs).
methodsUsing HPLC, including a new technique allowing quantification of feruloylquinic acid together with mangiferin, and histochemical methods, mangiferin content and tissue localization were compared in leaves and fruits of C. pseudozanguebariae, C. arabica and C. canephora. The HCE and mangiferin content of leaves was evaluated for 23 species native to Africa or Madagascar. Using various statistical methods, data were assessed in relation to distribution, ecology, phylogeny and use. KEY
resultsSeven of the 23 species accumulated mangiferin in their leaves. Mangiferin leaf-accumulating species also contain mangiferin in the fruits, but only in the outer (sporophytic) parts. In both leaves and fruit, mangiferin accumulation decreases with ageing. A relationship between mangiferin accumulation and UV levels is posited, owing to localization with photosynthetic tissues, and systematic distribution in high altitude clades and species with high altitude representatives. Analyses of mangiferin and HCE content showed that there are significant differences between species, and that samples can be grouped into species, with few exceptions. These data also provide independent support for various Coffea lineages, as proposed by molecular phylogenetic analyses. Sampling of the hybrids C. arabica and C. heterocalyx cf. indicates that mangiferin and HCE accumulation may be under independent parental influence.
conclusionsThis survey of the phenolic composition in Coffea leaves shows that mangiferin and HCE accumulation corresponds to lineage recognition and species delimitation, respectively. Knowledge of the spectrum of phenolic accumulation within species and populations could be of considerable significance for adaptation to specific environments. The potential health benefits of coffee-leaf tea, and beverages and masticatory products made from the fleshy parts of Coffea fruits, are supported by our phenolic quantification.
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