ArticleAmerican journal of physiology. Cell physiology2012
Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches.
Article in American journal of physiology. Cell physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
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- A multimodal microfluidic-based platform integrating topographical and equibiaxial mechanical cues for next-generationFrontiers in bioengineering and biotechnology · 2025Article
- Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics.Nature physics · 2025Article
- Impact of uniaxial cyclic stretching on matrix-associated endothelial cell responses.Materials today. Bio · 2024Article
- Cyclic Stretching Triggers Cell Orientation and Extracellular Matrix Remodeling in a Periodontal Ligament 3D In Vitro Model.Advanced healthcare materials · 2023Article
- Article
- Angiopoietin-like 4-Induced 3D Capillary Morphogenesis Correlates to Stabilization of Endothelial Adherens Junctions and Restriction of VEGF-Induced Sprouting.Biomedicines · 2022Article
- Substrate stiffening promotes VEGF-A functions via the PI3K/Akt/mTOR pathway.Biochemical and biophysical research communications · 2022Article
- Enhanced Platelet-Rich Plasma (ePRP) Stimulates Wound Healing through Effects on Metabolic Reprogramming in Fibroblasts.International journal of molecular sciences · 2021Article
- Cyclic stretching-induced epithelial cell reorientation is driven by microtubule-modulated transverse extension during the relaxation phase.Scientific reports · 2021Article
- Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology.Communications biology · 2021Review
- Single Cell Forces after Electroporation.ACS nano · 2021Article
- Epithelial layer unjamming shifts energy metabolism toward glycolysis.Scientific reports · 2020Article
- Structural and mechanical remodeling of the cytoskeleton maintains tensional homeostasis in 3D microtissues under acute dynamic stretch.Scientific reports · 2020Article
- Good advice for endothelial cells: Get in line, relax tension, and go with the flow.APL bioengineering · 2020Article
- Mechanobiology of dynamic enzyme systems.APL bioengineering · 2020Article
- Unleashing shear: Role of intercellular traction and cellular moments in collective cell migration.Biochemical and biophysical research communications · 2020Article
- Unjamming and collective migration in MCF10A breast cancer cell lines.Biochemical and biophysical research communications · 2020Article
- Mechanical signaling in a pulmonary microvascular endothelial cell monolayer.Biochemical and biophysical research communications · 2019Article
- Epithelial cells exert differential traction stress in response to substrate stiffness.Experimental eye research · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Mechanical stretch plays an important role in regulating shape and orientation of the vascular endothelial cell. This morphological response to stretch is basic to angiogenesis, neovascularization, and vascular homeostasis, but mechanism remains unclear. To elucidate mechanisms, we used cell mapping rheometry to measure traction forces in primary human umbilical vein endothelial cells subjected to periodic uniaxial stretches. Onset of periodic stretch of 10% strain amplitude caused a fluidization response typified by attenuation of traction forces almost to zero. As periodic stretch continued, the prompt fluidization response was followed by a slow resolidification response typified by recovery of the traction forces, but now aligned along the axis perpendicular to the imposed stretch. Reorientation of the cell body lagged reorientation of the traction forces, however. Together, these observations demonstrate that cellular reorientation in response to periodic stretch is preceded by traction attenuation by means of cytoskeletal fluidization and subsequent traction recovery transverse to the stretch direction by means of cytoskeletal resolidification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.