ArticleEndocrinology2012
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects.
Article in Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Ghrelin enhances tubular magnesium absorption in the kidney.Frontiers in physiology · 2024Article
- Role and molecular mechanism of ghrelin in degenerative musculoskeletal disorders.Journal of cellular and molecular medicine · 2023Review
- The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Bone Health after Bariatric Surgery: Consequences, Prevention, and Treatment.Advanced biomedical research · 2022Review
- Feeding intervention potentiates the effect of mechanical loading to induce new bone formation in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Ghrelin Gene Deletion Alters Pulsatile Growth Hormone Secretion in Adult Female Mice.Frontiers in endocrinology · 2021Article
- Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream.Scientific reports · 2020Article
- Physiological Effect of Ghrelin on Body Systems.International journal of endocrinology · 2020Review
- Capromorelin: a ghrelin receptor agonist and novel therapy for stimulation of appetite in dogs.Veterinary medicine and science · 2018Review
- The Role of Ghrelin and Ghrelin Signaling in Aging.International journal of molecular sciences · 2017Review
- Ghrelin plasma levels, gastric ghrelin cell density and bone mineral density in women with rheumatoid arthritis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Bone Cell Bioenergetics and Skeletal Energy Homeostasis.Physiological reviews · 2017Review
- The obesity of bone.Therapeutic advances in endocrinology and metabolism · 2015Review
- Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling.Molecular metabolism · 2015Article
- Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts.International journal of endocrinology · 2015Article
- Bone and mineral metabolism in patients undergoing Roux-en-Y gastric bypass.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- The hunger games of skeletal metabolism.BoneKEy reports · 2014Review
- Ghrelin: much more than a hunger hormone.Current opinion in clinical nutrition and metabolic care · 2013Review
- Beneficial association of serum ghrelin and peptide YY with bone mineral density in the Newfoundland population.BMC endocrine disorders · 2013Article
- Influence of hormonal appetite and energy regulators on bone.Current osteoporosis reports · 2013Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The mutual interplay between energy homeostasis and bone metabolism is an important emerging concept. Ghrelin and leptin antagonize each other in regulating energy balance, but the role of this interaction in bone metabolism is unknown. Using ghrelin receptor and leptin-deficient mice, we show that ghrelin has dual effects on osteoclastogenesis, inhibiting osteoclast progenitors directly and stimulating osteoclastogenesis via a more potent systemic/central pathway. Using mice with combined ghrelin receptor and leptin deficiency, we find that this systemic osteoclastogenic activity is suppressed by leptin, thus balancing the two counterregulatory ghrelin pathways and leading to an unchanged bone structure. With aging, this osteoclastogenic ghrelin pathway is lost, unmasking the direct protective effect of ghrelin on bone structure. In conclusion, we identify a novel regulatory network linking orexigenic and anorectic metabolic factors with bone metabolism that is age dependent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.