ArticleAJNR. American journal of neuroradiology2013
Factors influencing clinically meaningful recanalization after IV-rtPA in acute ischemic stroke.
Article in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Precision Medicine for Blood Glutamate Grabbing in Ischemic Stroke.International journal of molecular sciences · 2024Observational
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- Liver fibrosis-4 score predicts outcome of patients with ischemic stroke undergoing intravenous thrombolysis.Frontiers in neurology · 2023Article
- Early recanalization in large-vessel occlusion stroke patients transferred for endovascular treatment.Journal of neurointerventional surgery · 2022Article
- Perampanel Reduces Brain Damage via Induction of M2 Microglia in a Neonatal Rat Stroke Model.International journal of nanomedicine · 2022Article
- Single-phase CT angiography: collateral grade is independent of scan weighting.Neuroradiology · 2019Article
- Intravenous thrombolysis before endovascular therapy for large vessel strokes can lead to significantly higher hospital costs without improving outcomes.Journal of neurointerventional surgery · 2018Article
- Article
- Effect of Collaterals on Clinical Presentation, Baseline Imaging, Complications, and Outcome in Acute Stroke.AJNR. American journal of neuroradiology · 2015Article
- Predictors of reperfusion in patients with acute ischemic stroke.AJNR. American journal of neuroradiology · 2015Article
- Contribution and additional impact of imaging to the SPAN-100 score.AJNR. American journal of neuroradiology · 2015Article
- Endovascular therapy in hyperacute ischaemic stroke: history and current status.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background and purposeRecanalization may not result in better clinical outcomes after ischemic stroke. We determined the incidence and significant predictors of CMR, defined as CT angiographic recanalization and a good clinical outcome, after IV-rtPA in acute ischemic stroke. A CMR score was devised and tested. MATERIALS AND
methodsOne hundred twenty-six consecutive patients with anterior circulation ischemic stroke receiving IV-rtPA were retrospectively reviewed. Imaging included a baseline NCCT and CTA. Recanalization was assessed on a 24-hour CTA. Clinical outcome was determined by the 90-day mRS. CMR was defined as CTA recanalization and a good clinical outcome (mRS ≤2). Logistic regression analysis determined predictors of CMR. The predictive ability of a CMR score was tested with AIC.
resultsCMR occurred in 29% (36/126). Patients with CMR had fewer neurologic deficits (P = .001) and higher ASPECTS (P = .041) at baseline than those without CMR. Baseline NIHSS score did not predict proximal occlusion (OR 0.959; 95% CI [0.907-1.014]; P = .141). Multivariate analysis showed admission NIHSS score (P = .001) and the site of vessel occlusion (P = .022) to be significant CMR predictors. CMR was significantly less likely in patients with proximal occlusions (ICA, P = .005; proximal M1, P = .021). A CMR score better predicted CMR than either NIHSS or vessel occlusion site alone (P < .0001).
conclusionsMilder baseline stroke deficit and distal vessel occlusion are significant predictors of CMR. A combination of these parameters better predicts CMR than either parameter alone.
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