ArticleInvestigative ophthalmology & visual science2012
The heritability of macular response to supplemental lutein and zeaxanthin: a classic twin study.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial.JAMA ophthalmology · 2017Trial
- Review
- Macular and Plasma Xanthophylls Are Higher in Age-related Macular Degeneration than in Normal Aging: Alabama Study on Early Age-related Macular Degeneration 2 Baseline.Ophthalmology science · 2023Article
- Twins' Macular Pigment Optical Density Assessment and Relation with SCARB1 Gene Polymorphism.Genes · 2023Article
- Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population.Investigative ophthalmology & visual science · 2021Article
- From carotenoid intake to carotenoid blood and tissue concentrations - implications for dietary intake recommendations.Nutrition reviews · 2021Review
- The value of nutritional supplements in treating Age-Related Macular Degeneration: a review of the literature.International ophthalmology · 2019Review
- Repeatability of the macular pigment spatial profile: A comparison of objective versus subjective classification.Acta ophthalmologica · 2018Article
- What do we know about the macular pigment in AMD: the past, the present, and the future.Eye (London, England) · 2018Review
- Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration.International journal of ophthalmology · 2018Article
- Lutein and Zeaxanthin Isomers in Eye Health and Disease.Annual review of nutrition · 2016Review
- Macular Pigment Optical Density and Measures of Macular Function: Test-Retest Variability, Cross-Sectional Correlations, and Findings from the Zeaxanthin Pilot Study of Response to Supplementation (ZEASTRESS-Pilot).Foods (Basel, Switzerland) · 2016Article
- Measurement of macular pigment optical density among healthy Chinese people and patients with early-stage age-related macular degeneration.International journal of ophthalmology · 2015Article
- Effect of age and other factors on macular pigment optical density measured with resonance Raman spectroscopy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Macular xanthophylls, lipoprotein-related genes, and age-related macular degeneration.The American journal of clinical nutrition · 2014Review
- Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions.Current opinion in ophthalmology · 2014Review
- The heritability of the ring-like distribution of macular pigment assessed in a twin study.Investigative ophthalmology & visual science · 2014Article
- Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS).Investigative ophthalmology & visual science · 2014Article
- Article
- Candidate gene study of macular response to supplemental lutein and zeaxanthin.Experimental eye research · 2013Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeAntioxidant supplements may reduce age-related macular degeneration (AMD) progression. The macular carotenoids are of particular interest because of their biochemical, optical, and anatomic properties. This classic twin study was designed to determine the heritability of macular pigment (MP) augmentation in response to supplemental lutein (L) and zeaxanthin (Z).
methodsA total of 322 healthy female twin volunteers, aged 16-50 years (mean 40 ± 8.7) was enrolled in a prospective, nonrandomized supplement study. Macular pigment optical density (MPOD) measurements using two techniques (2-wavelength fundus autofluorescence [AF] and heterochromatic flicker photometry [HFP]), and serum concentrations of L and Z, were recorded at baseline, and at 3 and 6 months following daily supplementation with 18 mg L and 2.4 mg Z for a study period of 6 months.
resultsAt baseline, mean MPOD was 0.44 density units (SD 0.21, range 0.04-1.25) using HFP, and 0.41 density units (SD 0.15) using AF. Serum L and Z levels were raised significantly from baseline following 3 months' supplementation (mean increase 223% and 633%, respectively, P < 0.0001 for both), with no MPOD increase. After 6 months' supplementation, a small increase in MPOD was seen (mean increase 0.025 ± 0.16, P = 0.02, using HFP). Subdivision of baseline MPOD into quartiles revealed that baseline levels made no difference to the treatment effect. Genetic factors explained 27% (95% confidence interval [CI] 7-45) of the variation in MPOD response. Distribution profiles of macular pigment did not change in response to supplementation.
conclusionsMPOD response to supplemental L and Z for a period of 6 months was small (an increase over baseline of 5.7% and 3.7%, measured using HFP and AF, respectively), and was moderately heritable. Further study is indicated to investigate the functional and clinical impact of supplementation with the macular carotenoids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.