ArticleInvestigative ophthalmology & visual science2012
Neuroprotective effects of nonfeminizing estrogens in retinal photoreceptor neurons.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Retinal and choroidal changes in diabetic patients before definitive diagnosis of diabetic retinopathy: a two-year prospective study.Journal of endocrinological investigation · 2026Article
- A two sample Mendelian randomized study of the association of sex hormones and behavioral and clinical risk factors with macular hole.Scientific reports · 2025Article
- Etiology of Idiopathic Macular Holes in the Light of Estrogen Hormone.Current issues in molecular biology · 2023Review
- Sex-related differences in retinal function in Wistar rats: implications for toxicity and safety studies.Frontiers in toxicology · 2023Article
- Differential distribution of steroid hormone signaling networks in the human choroid-retinal pigment epithelial complex.BMC ophthalmology · 2022Article
- Article
- Girl Power in Glaucoma: The Role of Estrogen in Primary Open Angle Glaucoma.Cellular and molecular neurobiology · 2022Review
- Sex Hormones and Optic Nerve Disorders: A Review.Frontiers in neuroscience · 2019Review
- Impact of aromatase absence on murine intraocular pressure and retinal ganglion cells.Scientific reports · 2018Article
- Gonadal Hormones and Retinal Disorders: A Review.Frontiers in endocrinology · 2018Review
- The impact of combined oral contraceptives on ocular tissues: a review of ocular effects.International journal of ophthalmology · 2017Review
- Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia.Molecular neurobiology · 2016Article
- Oral Contraceptive Use and Prevalence of Self-Reported Glaucoma or Ocular Hypertension in the United States.Ophthalmology · 2016Article
- Cell surface translocation of annexin A2 facilitates glutamate-induced extracellular proteolysis.The Journal of biological chemistry · 2014Article
- Differences in neuroretinal function between adult males and females.Optometry and vision science : official publication of the American Academy of Optometry · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
purposeRetinal diseases such as macular degeneration and glaucoma are disorders that target specific retinal neurons that can ultimately lead to vision loss. Under these conditions and pathologies, retinal neurons can die via apoptosis that may be due to increased oxidative stress. The neuroprotective effects of 17β-estradiol (E2) and three synthetic nonfeminizing estrogen analogs (ZYC-26, ZYC-23, and ZYC-3) were investigated to examine their abilities to protect retinal neurons against glutamate toxicity.
methodsUsing an in vitro model of glutamate-induced cell death in 661W cells, a mouse cone photoreceptor cell line, shown to express both estrogen receptors (ERs) via immunoblotting, was pretreated with E2 and its analogs and cell viability were assessed.
resultsIt was observed that E2 and estrogen analogs, ZYC-26 and ZYC-3, were protective against a 5 mM glutamate insult in 661W cells. The neuroprotective abilities of ZYC-26 and ZYC-3 were autonomous of estrogen receptor-α (ERα) and ERβ demonstrated by their ability to protect in the presence of ICI 182780, a pan-ER antagonist with a high affinity for the estrogen receptor. Treatment with PPT and DPN, ERα- and ERβ-specific agonists, respectively, did not protect the 661W cells from the glutamate insult. Studying the membrane ER (mER) or GPR30 did show that activation of the receptor by G1 protected the retinal neuron from insult, whereas G15, an antagonist of the mER was not able to antagonize the protection previously seen.
conclusionsThese data demonstrate that nonfeminizing estrogens may emerge as useful compounds for neuroprotection of retinal cells.
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