Evidence map›Paper›PMID 22700402›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2012

High-resolution in vivo imaging of fluorescent proteins using window chamber models.

Gregory M Palmer, Andrew N Fontanella, Siqing Shan, Mark W Dewhirst

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  8. Clinical development of new drug-radiotherapy combinations.Nature reviews. Clinical oncology · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gregory M PalmerDepartment of Radiation Oncology, Duke University, Durham, NC, USA. greg.palmer@duke.edu
Andrew N Fontanella
Siqing Shan
Mark W Dewhirst

Funding

Heat And Radiation Effects On Tumor MicrocirulationR01CA040355 · NCI · DUKE UNIVERSITY · PI DEWHIRST, MARK WESLEY · 1985 to 2013
$4.5M
NCI NIH HHS R01 CA040355NCI NIH HHS R01 - CA40355-26
6 · The paper itself

Abstract

Fluorescent proteins enable in vivo characterization of a wide and growing array of morphological and functional biomarkers. To fully capitalize on the spatial and temporal information afforded by these reporter proteins, a method for imaging these proteins at high resolution longitudinally is required. This chapter describes the use of window chamber models as a means of imaging fluorescent proteins and other optical parameters. Such models essentially involve surgically implanting a window through which tumor or normal tissue can be imaged using existing microscopy techniques. This enables acquisition of high-quality images down to the cellular or subcellular scale, exploiting the diverse array of optical contrast mechanisms, while also maintaining the native microenvironment of the tissue of interest. This makes these techniques applicable to a wide array of problems in the biomedical sciences.

Indexed as

FluorescenceAnimalsDiagnostic ImagingGreen Fluorescent ProteinsNeoplasmsGreen Fluorescent Proteins

Identifiers

PMID22700402
PMCPMC3736593

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.