ArticleJournal of molecular neuroscience : MN2013
Comprehensive gene expression analysis of cerebral cortices from mature rats after neonatal hypoxic-ischemic brain injury.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Identification and clinical validation of F3 as a peripheral blood biomarker for neonatal hypoxic-ischemic encephalopathy using dataset-specific bioinformatics analysis.Frontiers in pediatrics · 2026Article
- P4HA1 Regulates CD31Frontiers in oncology · 2022Article
- Review
- Article
- MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1.Molecular neurobiology · 2020Article
- Proteomic Advances in Glial Tumors through Mass Spectrometry Approaches.Medicina (Kaunas, Lithuania) · 2019Review
- Decreased expression of ubiquilin‑1 following neonatal hypoxia‑ischemic brain injury in mice.Molecular medicine reports · 2019Article
- Hypoxic-ischemic neonatal encephalopathy: animal experiments for neuroprotective therapies.Stroke research and treatment · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
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Abstract
Neonatal hypoxic-ischemic (HI) encephalopathy can lead to severe brain damage and is a common cause of neurological handicaps in adulthood. To elucidate the molecular events occurring in cerebral cortices of mature rats (8 weeks old) after neonatal HI brain insult, we performed comprehensive gene expression and gene network analyses using a DNA microarray system (Agilent 4x44K). A rat model of neonatal HI encephalopathy (Rice model) was obtained by unilateral ligation of the common carotid artery of 7-day-old rats with hypoxia (exposure to 8 % oxygen). Due to the HI insult-related breakdown of the ipsilateral hemisphere in the brain, RNAs were prepared from the contralateral cerebral cortices of 8-week-old rats and analyzed by DNA microarray. Biofunctional analysis of differentially regulated genes revealed that many upregulated genes were related to cell death signaling, such as the arachidonic acid cascade. In contrast, many downregulated genes were related to gene expression, reflecting progressive damage by the HI insult, even within the contralateral cerebral hemisphere.
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