ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
Mammalian Sulf1 RNA alternative splicing and its significance to tumour growth regulation.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Get Spliced: Uniting Alternative Splicing and Arthritis.International journal of molecular sciences · 2024Review
- 6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets.American journal of cancer research · 2024Review
- Context Dependent Sulf1/Sulf2 Functional Divergence in Endothelial Cell Activity.International journal of molecular sciences · 2022Article
- Screening of Prognostic Markers for Hepatocellular Carcinoma Patients Based on Multichip Combined Analysis.Computational and mathematical methods in medicine · 2022Article
- Modulation of cell signalling and sulfation in cardiovascular development and disease.Scientific reports · 2021Article
- Screening Hub Genes of Hepatocellular Carcinoma Based on Public Databases.Computational and mathematical methods in medicine · 2021Article
- HS and Inflammation: A Potential Playground for the Sulfs?Frontiers in immunology · 2020Review
- Screening and identification of key biomarkers in hepatocellular carcinoma: Evidence from bioinformatic analysis.Oncology reports · 2017Article
- Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.Scientific reports · 2017Article
- Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling.Histochemistry and cell biology · 2016Article
- SULF1/SULF2 reactivation during liver damage and tumour growth.Histochemistry and cell biology · 2016Article
- Identification of important long non-coding RNAs and highly recurrent aberrant alternative splicing events in hepatocellular carcinoma through integrative analysis of multiple RNA-Seq datasets.Molecular genetics and genomics : MGG · 2016Article
- Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.Histochemistry and cell biology · 2016Article
- SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique.Iranian journal of reproductive medicine · 2015Article
- Proteoglycans and their roles in brain cancer.The FEBS journal · 2013Review
- Restoration of epigenetically silenced SULF1 expression by 5-aza-2-deoxycytidine sensitizes hepatocellular carcinoma cells to chemotherapy-induced apoptosis.Medical epigeneticsArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
SULF1/SULF2 enzymes regulate the activities of several growth factors by selective hydrolysis of 6-O-sulphates of heparan sulphate proteoglycan co-receptors, the sulfation of which is essential for signal transduction of some ligand/receptor interactions but not others. This study demonstrates the existence of SULF1 variants with a wide spectrum of splicing patterns in mammalian tumours. The levels and relative proportions of SULF1/SULF2 splice variants markedly vary in different tumours with a potential to regulate cell growth differentially. Although mammalian Sulf1 compared with Sulf2 gene generates a much larger number of splice variants, both enzymes follow generally similar distribution and signalling association trends in hepatocellular carcinomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.