ArticlePharmacopsychiatry2013
Antidepressants and anti-inflammatory drugs differentially reduce the release of NGF and BDNF from rat platelets.
Article in Pharmacopsychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Antidepressant-like effects of Ashwagandha (Withania Somnifera) on chronic unpredictable mild stress-induced depression in adolescent rats.Psychopharmacology · 2026Article
- Sustained long-term benefits of autologous subconjunctival platelet-rich plasma injections for severe dry eye disease.Regenerative medicine · 2025Article
- Review
- Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The Multifaceted Effects of Non-Steroidal and Non-Opioid Anti-Inflammatory and Analgesic Drugs on Platelets: Current Knowledge, Limitations, and Future Perspectives.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Basal myokine levels are associated with quality of life and depressed mood in older adults.Psychophysiology · 2021Article
- Therapeutic Potentials ofLife (Basel, Switzerland) · 2021Article
- The Role of Chinese Herbal Therapy in Methamphetamine Abuse and its Induced Psychiatric Symptoms.Frontiers in pharmacology · 2021Review
- Brain-derived neurotrophic factor is related to stress and chewing in saliva and salivary glands.The Japanese dental science review · 2020Review
- Depression and Cardiovascular Disease: The Viewpoint of Platelets.International journal of molecular sciences · 2020Review
- Postnatal Antioxidant and Anti-inflammatory Treatments Prevent Early Ketamine-Induced Cortical Dysfunctions in Adult Mice.Frontiers in neuroscience · 2020Article
- Plasma BDNF and TrkB mRNA in PBMCs Are Correlated With Anti-depressive Effects of 12-Weeks Supervised Exercise During Protracted Methamphetamine Abstinence.Frontiers in molecular neuroscience · 2020Article
- The Impact of Immunological Factors on Depression Treatment - Relation Between Antidepressants and Immunomodulation Agents.Open access Macedonian journal of medical sciences · 2019Review
- Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis.Scientific reports · 2019Article
- Nerve Growth Factor Serum Levels Are Associated With Regional Gray Matter Volume Differences in Schizophrenia Patients.Frontiers in psychiatry · 2019Article
- Peripheral Blood Brain-Derived Neurotrophic Factor as a Biomarker of Alzheimer's Disease: Are There Methodological Biases?Molecular neurobiology · 2018Review
- Are the changes in the peripheral brain-derived neurotrophic factor levels due to platelet activation?World journal of psychiatry · 2016Review
- Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and Therapy.Molecular neurobiology · 2015Article
- The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema.Iranian journal of basic medical sciences · 2015Article
- Platelet-derived nerve growth factor supports the survival of cholinergic neurons in organotypic rat brain slices.Neuroscience letters · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionPlatelets store serotonin and brain-derived neurotrophic factor (BDNF) as well as amyloid precursor protein and nerve growth factor (NGF), thus platelets are of special interest in depression and Alzheimer's disease, respectively. Both diseases are associated with inflammation and release of NGF or BDNF from platelets may play a potent role.
methodsPlatelets were isolated from adult Sprague-Dawley rats and were incubated with anti-inflammatory drugs (ibuprofen and indomethacin) and antidepressants (citalopram, paroxetine and sertraline) (final concentration: 0.3 µM) with or without 2 mM calcium chloride. The release of NGF and BDNF was analyzed in comparison to serotonin release from rat platelets after 10 or 60 min.
resultsSpontaneous release of serotonin and BDNF was approximately 10-15% of total serotonin or BDNF content in platelets, but nearly all NGF was released within 10 min. All antidepressants increased the serotonin release from rat platelets. NGF release was reduced by sertraline, paroxetine and ibuprofen, but only when calcium was present, except for sertraline after 10 min. BDNF release was only reduced by ibuprofen when calcium was added.
conclusionWe conclude that antidepressants and anti-inflammatory drugs differentially influence the NGF and BDNF release, in a time-, dose- and calcium-specific pattern.
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