ArticleJournal of cancer research and clinical oncology2012
Expression and biological role of δ-catenin in human ovarian cancer.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Spatial transcriptomics profiling across tissue boundaries in the developing mouse brain.iScience · 2026Article
- Effects of the carcinogen TCDD on δ-catenin stability and tumorigenic potential in prostate cancer cells.American journal of cancer research · 2025Article
- δ-Catenin promotes cell migration and invasion via Bcl-2-regulated suppression of autophagy in prostate cancer cells.American journal of cancer research · 2022Article
- bFGF-mediated phosphorylation of δ-catenin increases its protein stability and the ability to induce the nuclear redistribution of β-catenin.American journal of cancer research · 2021Article
- Intratumor δ-catenin heterogeneity driven by genomic rearrangement dictates growth factor dependent prostate cancer progression.Oncogene · 2020Article
- p300/CBP-associated factor promotes autophagic degradation of δ-catenin through acetylation and decreases prostate cancer tumorigenicity.Scientific reports · 2019Article
- δ-Catenin as a potential cancer biomarker.Pathology international · 2014Article
- C-Src-mediated phosphorylation of δ-catenin increases its protein stability and the ability of inducing nuclear distribution of β-catenin.Biochimica et biophysica acta · 2014Article
- Co-expression of delta-catenin and RhoA is significantly associated with a malignant lung cancer phenotype.International journal of clinical and experimental pathology · 2014Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveδ-Catenin is found to be involved in the progression of several human cancers. However, its expression pattern and biological roles in human ovarian cancers are not clear. In this study, we examined the expression pattern of δ-catenin in 149 ovarian cancer specimens. We also depleted and overexpressed δ-catenin expression in ovarian cancer cell lines and investigated its role in cell proliferation and invasion.
methodsδ-Catenin expression was analyzed in 149 archived ovarian cancer specimens using immunohistochemistry. siRNA knockdown and plasmid transfection were performed in SKOV3, SW626, and OVCAR3 cell lines. MTT, colony formation assay, soft agar colony assay, and matrigel invasion assay were carried out to assess the role of δ-catenin in cell proliferation and invasion. We also performed cell cycle analysis in δ-catenin depleted and overexpressed cells. In addition, we examined the level of several cell cycle-related molecules using Western blot.
resultsOf the 149 patients in the study, 104 (69.7 %) showed δ-catenin overexpression. δ-catenin overexpression positively correlated with advanced FIGO stage. δ-Catenin depletion in ovarian cancer cell lines inhibited ovarian cancer cell proliferation and invasion. Depletion of δ-catenin also blocked cell cycle progression and downregulated cyclin D1 expression in ovarian cancer cells. Overexpression of δ-catenin enhanced cell proliferation, invasion, and upregulated cyclinD1 expression.
conclusionsδ-Catenin is overexpressed in ovarian cancers and associated with advanced stage. Our data provide evidence that δ-catenin regulates the ovarian cancer cell proliferation, invasion, and cell cycle. δ-Catenin thus has potential as a therapeutic target.
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