ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Mechanisms shaping the slow nicotinic synaptic current at the motoneuron-renshaw cell synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 37 citations in OpenAlex.
- Synaptotagmin-7 facilitates acetylcholine release in splanchnic nerve-chromaffin cell synapses during nerve activity.Neuroscience letters · 2023Article
- On the Diverse Functions of Electrical Synapses.Frontiers in cellular neuroscience · 2022Review
- αFrontiers in neural circuits · 2021Article
- Motor units as tools to evaluate profile of human Renshaw inhibition.The Journal of physiology · 2019Article
- Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Recurrent excitation between motoneurones propagates across segments and is purely glutamatergic.PLoS biology · 2018Article
- Ultrafast and Slow Cholinergic Transmission. Different Involvement of Acetylcholinesterase Molecular Forms.Molecules (Basel, Switzerland) · 2017Review
- Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.Scientific reports · 2017Article
- Dendro-dendritic cholinergic excitation controls dendritic spike initiation in retinal ganglion cells.Nature communications · 2017Article
- Synchrony and so much more: Diverse roles for electrical synapses in neural circuits.Developmental neurobiology · 2017Review
- The Preparation of Oblique Spinal Cord Slices for Ventral Root Stimulation.Journal of visualized experiments : JoVE · 2016Article
- Developmental changes in the morphology of mouse hypoglossal motor neurons.Brain structure & function · 2016Article
- Synaptic Connectivity between Renshaw Cells and Motoneurons in the Recurrent Inhibitory Circuit of the Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Potassium currents dynamically set the recruitment and firing properties of F-type motoneurons in neonatal mice.Journal of neurophysiology · 2015Article
- Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.Frontiers in cellular neuroscience · 2015Article
- Article
- High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses.The Journal of physiology · 2014Review
- Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by α7 nicotinic receptors and butyrylcholinesterase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Motor axon synapses on renshaw cells contain higher levels of aspartate than glutamate.PloS one · 2014Article
- Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit.Annals of the New York Academy of Sciences · 2013Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spinal cord slices from newborn mice we have analyzed the kinetics of the EPSCs mediated by heteromeric nicotinic receptors at the motoneuron-Renshaw cell (MN-RC) synapse. The miniature EPSCs decay with a time constant of 13.0 ± 1.1 ms whereas the decay of the evoked EPSCs (eEPSCs) is biphasic, with time constants of 15.6 ± 0.8 and 124.8 ± 9.0 ms. The slow component becomes prominent during a repetitive stimulation, but its time constant is unchanged. It is selectively reduced by the addition of acetylcholinesterase (AChE), and thus appears to involve ACh spillover. The constancy of the slow time constant during a train is best explained by a local spillover activating high-affinity receptors. In many cells a fraction of the eEPSC originates in neighboring RCs and is transmitted by the low-pass filter of the gap junctions. The component transmitted electrically can be eliminated by meclofenamic acid, a blocker of gap junctions. The local spillover produced by a repetitive stimulation was compared with the long-range spillover produced by inactivation of AChE. The pharmacological inactivation of AChE by neostigmine caused the appearance of an ultra-slow (second range) decay component in eEPSCs and also a continuous inward current interpreted as resulting from a continuous ACh presence. In animals lacking functional AChE in the CNS (PRiMA(-/-) mice) the EPSCs resembled those observed in neostigmine but the steady inward current was much smaller, suggesting an adaptation to the absence of AChE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.