ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Changing neuroestrogens within the auditory forebrain rapidly transform stimulus selectivity in a downstream sensorimotor nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 83 citations in OpenAlex.
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- Social and auditory experience shapes forebrain responsiveness in zebra finches before the sensitive period of vocal learning.The Journal of experimental biology · 2024Article
- Auditory pallial regulation of the social behavior network.Communications biology · 2024Article
- Estrogens rapidly shape synaptic and intrinsic properties to regulate the temporal precision of songbird auditory neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex.Neural plasticity · 2023Article
- A neural circuit perspective on brain aromatase.Frontiers in neuroendocrinology · 2022Review
- Non-sensory Influences on Auditory Learning and Plasticity.Journal of the Association for Research in Otolaryngology : JARO · 2022Review
- Aromatase and nonaromatase neurons in the zebra finch secondary auditory forebrain are indistinct in their song-driven gene induction and intrinsic electrophysiological properties.The European journal of neuroscience · 2021Article
- Rapid changes in brain estrogen concentration during male sexual behavior are site and stimulus specific.Scientific reports · 2021Article
- Genetically identified neurons in avian auditory pallium mirror core principles of their mammalian counterparts.Current biology : CB · 2021Article
- Sex differences and similarities in the neural circuit regulating song and other reproductive behaviors in songbirds.Neuroscience and biobehavioral reviews · 2020Review
- Testosterone synthesis in the female songbird brain.Hormones and behavior · 2020Article
- Neuroestrogen synthesis modifies neural representations of learned song without altering vocal imitation in developing songbirds.Scientific reports · 2020Article
- Life-Stage Dependent Plasticity in the Auditory System of a Songbird Is Signal and Emitter-Specific.Frontiers in neuroscience · 2020Article
- Estradiol rapidly modulates excitatory synapse properties in a sex- and region-specific manner in rat nucleus accumbens core and caudate-putamen.Journal of neurophysiology · 2019Article
- Hormonal regulation of social ascent and temporal patterns of behavior in an African cichlid.Hormones and behavior · 2019Article
- Neuroestrogens rapidly shape auditory circuits to support communication learning and perception: Evidence from songbirds.Hormones and behavior · 2018Review
- A Membrane G-Protein-Coupled Estrogen Receptor Is Necessary but Not Sufficient for Sex Differences in Zebra Finch Auditory Coding.Endocrinology · 2018Article
- On the role of brain aromatase in females: why are estrogens produced locally when they are available systemically?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Norepinephrine enhances song responsiveness and encoding in the auditory forebrain of male zebra finches.Journal of neurophysiology · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The activity of sensory circuits is shaped by neuromodulators, which can have downstream consequences for both sensorimotor integration and behavioral output. Recent evidence indicates that brain-derived estrogens ("neuroestrogens") can act as local circuit modulators in the songbird auditory forebrain. Specifically, neuroestrogens fluctuate in the auditory caudomedial nidopallium (NCM) during social interactions and in response to song stimuli. Within minutes of elevation, neuroestrogens also enhance auditory response properties of NCM neurons, and acute blockade of estrogen production in NCM disrupts behavioral song preferences. Here, we test the hypothesis that fluctuating neuroestrogens within NCM influence stimulus selectivity in a downstream sensorimotor nucleus (HVC, used as a proper name) that receives indirect auditory input from NCM. Dual extracellular recordings coupled with retrodialysis delivery show that song selectivity in HVC is rapidly enhanced by increasing neuroestrogens in NCM in adult males. Conversely, inhibiting neuroestrogen production in NCM causes a rapid decline in song selectivity in HVC, demonstrating the endogenous nature of this modulatory network. In contrast, HVC selectivity is unaffected by neuroestrogen delivery to either nearby caudomedial mesopallium or into HVC itself, indicating that neuroestrogen actions are restricted to NCM. In juvenile males, identical neuroestrogen treatment in NCM also does not alter HVC selectivity, consistent with a developmental maturation of the auditory network. Lastly, the rapid actions of estrogens leading to enhanced HVC selectivity appear to be mediated by membrane-bound receptors in NCM. These findings indicate that steroid-dependent modulation of sensory processing is not locally restricted and can be transmitted transynaptically to influence downstream sensorimotor and premotor targets.
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