Evidence map›Paper›PMID 22699831›Full record

ReviewNature reviews. Immunology2012

Information processing during phagocytosis.

David M Underhill, Helen S Goodridge

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 280 papers.

0numbers the graph read from it
0cells of the map it votes in
280citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

280 citing papers in PubMed.

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220 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David M UnderhillInflammatory Bowel & Immunobiology Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8,700 Beverly Boulevard, Los Angeles, California 90048, USA. David.Underhill@csmc.edu
Helen S Goodridge

Funding

Phagosomal targeting of CARD proteinsR01GM085796 · NIGMS · CEDARS-SINAI MEDICAL CENTER · PI UNDERHILL, DAVID M. · 2008 to 2020
$4.1M
NIGMS NIH HHS R01 GM085796
6 · The paper itself

Abstract

Phagocytosis - the process by which macrophages, dendritic cells and other myeloid phagocytes internalize diverse particulate targets - is a key mechanism of innate immunity. The molecular and cellular events that underlie the binding of targets to a phagocyte and their engulfment into phagosomes have been extensively studied. More recent data suggest that the process of phagocytosis itself provides information to myeloid phagocytes about the nature of the targets they are engulfing and that this helps to tailor inflammatory responses. In this Review, we discuss how such information is acquired during phagocytosis and how it is processed to coordinate an immune response.

Indexed as

AnimalsHumansImmunity, InnateInflammasomesMacrophagesModels, ImmunologicalMyeloid CellsPhagocytesPhagocytosisReceptors, ImmunologicSignal TransductionToll-Like ReceptorsInflammasomesReceptors, ImmunologicToll-Like Receptors

Identifiers

PMID22699831
PMCPMC5570470

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.