Evidence map›Paper›PMID 22699553›Full record

ReviewRNA biology2012

Involvement of long noncoding RNAs in diseases affecting the central nervous system.

Chiara Pastori, Claes Wahlestedt

Abstract readReview
In one paragraph

Review in RNA biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Genetics of neurosarcoidosis.Journal of neuroimmunology · 2022
    Review
  5. Article
  6. Review
  7. DLX6-AS1: A Long Non-coding RNA With Oncogenic Features.Frontiers in cell and developmental biology · 2022
    Review
  8. Neurobiological Opportunities in Diabetic Polyneuropathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chiara PastoriDepartment of Psychiatry and Behavioral Sciences and Center for Therapeutic Innovation, Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Claes Wahlestedt

Funding

Comprehensive analysis of the FMR1 locus transcriptional landscapeR01MH084880 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WAHLESTEDT, CLAES ROBERT · 2010 to 2014
$2.0M
Regulatory RNAs as mediators and biomarkers in Alzheimer's DiseaseR01NS063974 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WAHLESTEDT, CLAES ROBERT · 2009 to 2012
$1.6M
NIMH NIH HHS 5R01MH084880NIMH NIH HHS R01 MH084880NINDS NIH HHS 5R01NS063974NINDS NIH HHS R01 NS063974
6 · The paper itself

Abstract

DNA sequences associated with protein-coding genes have been the primary focus of most genetic analyses of complex human diseases. Although we are rapidly gaining a comprehensive view of the etiology of certain central nervous system disorders, major gaps in our understanding persist. Recent studies have uncovered that many human genomic sequences are transcribed but not translated, generating an astounding diversity of noncoding RNAs (ncRNAs). This awareness should be taken into account when studying human diseases and may have profound implications on the development of novel biomarkers as well as therapies.

Indexed as

AnimalsBrain NeoplasmsChromosome DisordersGene ExpressionGene Expression RegulationGenomic ImprintingHumansNeurodegenerative DiseasesRNA, Long NoncodingRNA, Long Noncoding

Identifiers

PMID22699553
PMCPMC3495748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.