Trial reportEuropean journal of nuclear medicine and molecular imaging2012
Assessment of response of brain metastases to radiotherapy by PET imaging of apoptosis with ¹⁸F-ML-10.
Trial report in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed.
- [18F]ML-10 Imaging for Assessment of Apoptosis Response of Intracranial Tumor Early after Radiosurgery by PET/CT.Contrast media & molecular imaging · 2018Trial
- Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026Review
- Augmentation of [EJNMMI research · 2025Article
- The therapeutic effect of a novel GAPDH inhibitor in mouse model of breast cancer and efficacy monitoring by molecular imaging.Cancer cell international · 2024Article
- Proliferation and apoptosis after whole-body irradiation: longitudinal PET study in a mouse model.European journal of nuclear medicine and molecular imaging · 2024Article
- Review
- Comparison of [Scientific reports · 2023Article
- Detection of apoptosis by [Annals of nuclear medicine · 2023Article
- Detection of cardiac apoptosis by [Molecular imaging and biology · 2022Article
- Radionuclide imaging of apoptosis for clinical application.European journal of nuclear medicine and molecular imaging · 2022Review
- Apoptosis Imaging in Oncology by Means of Positron Emission Tomography: A Review.International journal of molecular sciences · 2021Review
- Interest and Limits of [Frontiers in oncology · 2021Review
- Targeting Phosphatidylethanolamine with Fluorine-18 Labeled Small Molecule Probe for Apoptosis Imaging.Molecular imaging and biology · 2020Article
- [EJNMMI research · 2020Article
- Review
- Investigation of cis-4-[Molecular imaging and biology · 2018Article
- Clinical translation of [European journal of nuclear medicine and molecular imaging · 2018Article
- Avenues to molecular imaging of dying cells: Focus on cancer.Medicinal research reviews · 2018Review
- Downregulation of Survivin Gene Expression Affects Ionizing Radiation Resistance of Human T98 Glioma Cells.Cellular and molecular neurobiology · 2018Article
- SPECT and PET radiopharmaceuticals for molecular imaging of apoptosis: from bench to clinic.Oncotarget · 2017Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEarly assessment of tumor response to therapy is vital for treatment optimization for the individual cancer patient. Induction of apoptosis is an early and nearly universal effect of anticancer therapies. The purpose of this study was to assess the performance of (18)F-ML-10, a novel PET radiotracer for apoptosis, as a tool for the early detection of response of brain metastases to whole-brain radiation therapy (WBRT). MATERIALS AND
methodsTen patients with brain metastases treated with WBRT at 30 Gy in ten daily fractions were enrolled in this trial. Each patient underwent two (18)F-ML-10 PET scans, one prior to the radiation therapy (baseline scan), and the second after nine or ten fractions of radiotherapy (follow-up scan). MRI was performed at 6-8 weeks following completion of the radiation therapy. Early treatment-induced changes in tumor (18)F-ML-10 uptake on the PET scan were measured by voxel-based analysis, and were then evaluated by correlation analysis as predictors of the extent of later changes in tumor anatomical dimensions as seen on MRI scans 6-8 weeks after completion of therapy.
resultsIn all ten patients, all brain lesions were detected by both MRI and the (18)F-ML-10 PET scan. A highly significant correlation was found between early changes on the (18)F-ML-10 scan and later changes in tumor anatomical dimensions (r = 0.9).
conclusionThese results support the potential of (18)F-ML-10 PET as a novel tool for the early detection of response of brain metastases to WBRT.
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