ArticleProceedings of the National Academy of Sciences of the United States of America2012
Evolution of Fe/S cluster biogenesis in the anaerobic parasite Blastocystis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 78 citations in OpenAlex.
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- Environment-dependent mutualism-parasitism transitions in the incipient symbiosis between Tetrahymena utriculariae and Micractinium tetrahymenae.The ISME journal · 2025Article
- Extreme mitochondrial reduction in a novel group of free-living metamonads.Nature communications · 2024Article
- Review
- Components of iron-Sulfur cluster assembly machineries are robust phylogenetic markers to trace the origin of mitochondria and plastids.PLoS biology · 2023Article
- Resistance of Blastocystis to chlorine and hydrogen peroxide.Parasitology research · 2023Article
- Molecular Characterization ofAnimals : an open access journal from MDPI · 2021Article
- Genome Analysis of a Verrucomicrobial Endosymbiont With a Tiny Genome Discovered in an Antarctic Lake.Frontiers in microbiology · 2021Article
- Article
- Multilayered horizontal operon transfers from bacteria reconstruct a thiamine salvage pathway in yeasts.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Successful Genetic Transfection of the Colonic Protistan Parasite Blastocystis for Reliable Expression of Ectopic Genes.Scientific reports · 2019Article
- On the Origin of Iron/Sulfur Cluster Biosynthesis in Eukaryotes.Frontiers in microbiology · 2019Article
- Localization of Fe-S Biosynthesis Machinery in Cryptosporidium parvum Mitosome.The Journal of eukaryotic microbiology · 2018Article
- Fe-S cluster assembly in the supergroup Excavata.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- Iron-sulfur clusters biogenesis by the SUF machinery: close to the molecular mechanism understanding.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2018Review
- The Human Gut ColonizerFrontiers in cellular and infection microbiology · 2018Article
- Large-scale comparative metagenomics of Blastocystis, a common member of the human gut microbiome.The ISME journal · 2017Article
- Molecular characterization of Blastocystis sp. in captive wild animals in Qinling Mountains.Parasitology research · 2017Article
- Protist Evolution: Stealing Genes to Gut It Out.Current biology : CB · 2017Article
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
Iron/sulfur cluster (ISC)-containing proteins are essential components of cells. In most eukaryotes, Fe/S clusters are synthesized by the mitochondrial ISC machinery, the cytosolic iron/sulfur assembly system, and, in photosynthetic species, a plastid sulfur-mobilization (SUF) system. Here we show that the anaerobic human protozoan parasite Blastocystis, in addition to possessing ISC and iron/sulfur assembly systems, expresses a fused version of the SufC and SufB proteins of prokaryotes that it has acquired by lateral transfer from an archaeon related to the Methanomicrobiales, an important lineage represented in the human gastrointestinal tract microbiome. Although components of the Blastocystis ISC system function within its anaerobic mitochondrion-related organelles and can functionally replace homologues in Trypanosoma brucei, its SufCB protein has similar biochemical properties to its prokaryotic homologues, functions within the parasite's cytosol, and is up-regulated under oxygen stress. Blastocystis is unique among eukaryotic pathogens in having adapted to its parasitic lifestyle by acquiring a SUF system from nonpathogenic Archaea to synthesize Fe/S clusters under oxygen stress.
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