Evidence map›Paper›PMID 22698992›Full record

ArticleBrain, behavior, and immunity2013

Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors.

Shelli Kesler, Michelle Janelsins, Della Koovakkattu, Oxana Palesh, Karen Mustian, Gary Morrow, Firdaus S Dhabhar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed, 12 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

194 citing papers in PubMed, 12 syntheses or guidelines pooled it, 311 citations in OpenAlex.

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  11. Modifiable factors and cognitive dysfunction in breast cancer survivors: a mixed-method systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
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  15. Effects of Baduanjin exercise on cognitive function and cancer-related symptoms in women with breast cancer receiving chemotherapy: a randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shelli KeslerDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. skesler@stanford.edu
Michelle Janelsins
Della Koovakkattu
Oxana Palesh
Karen Mustian
Gary Morrow
Firdaus S Dhabhar
Stanford University · USUniversity of Rochester · USStanford Medicine · US

Funding

UNIVERSITY OF ROCHESTER--CCOP RESEARCH BASEU10CA037420 · NCI · UNIVERSITY OF ROCHESTER · PI MORROW, GARY R · 1985 to 2014
$21.1M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
Assessment and Treatment of Cognitive Deficits in Breast CancerDP2OD004445 · OD · STANFORD UNIVERSITY · PI KESLER, SHELLI R · 2008 to 2008
$2.4M
Neurobiologic Mechanisms of Cognitive Dysfunction and Decline in MedulloblastomaK07CA134639 · NCI · STANFORD UNIVERSITY · PI KESLER, SHELLI R · 2009 to 2013
$823k
Interventions Targeting Inflammation for Chemotherapy-Related Cognitive ProblemsK07CA168886 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2013 to 2017
$724k
NCI NIH HHS K07 CA134639NCI NIH HHS K07 CA168886NCI NIH HHS R25 CA102618NCI NIH HHS U10 CA037420NIH HHS 1 DP2 OD004445-01NIH HHS DP2 OD004445
6 · The paper itself

Abstract

Many survivors of breast cancer show significant cognitive impairments, including memory deficits. Inflammation induced by chemotherapy may contribute to hippocampal changes that underlie these deficits. In this cross-sectional study, we measured bilateral hippocampal volumes from high-resolution magnetic resonance images in 42 chemotherapy-treated breast cancer survivors and 35 healthy female controls. Patients with breast cancer were, on average, 4.8 ± 3.4 years off-therapy. In a subset of these participants (20 breast cancer, 23 controls), we quantified serum cytokine levels. Left hippocampal volumes and memory performance were significantly reduced and interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) concentrations were significantly elevated in the breast cancer group compared to controls. In the breast cancer group, lower left hippocampal volume was associated with higher levels of TNFα and lower levels of IL-6 with a significant interaction between these two cytokines suggesting a potential modulatory effect of IL-6 on TNFα. Verbal memory performance was associated with cytokine levels and left hippocampal volume in both groups. These findings provide evidence of altered hippocampal volume and verbal memory difficulties following breast cancer chemotherapy that may be mediated by TNFα and IL-6.

Indexed as

MemoryAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsCognition DisordersCross-Sectional StudiesFemaleHippocampusHumansInterleukin-6Magnetic Resonance ImagingMiddle AgedNeuropsychological TestsSurvivorsTumor Necrosis Factor-alphaInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID22698992
PMCPMC3665606
OpenAlexW2137323524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.