ArticleInternational journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2012
Ontogeny and the effects of in utero brain ischemia on interleukin-1β and interleukin-6 protein expression in ovine cerebral cortex and white matter.
Article in International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Strategies for blood-brain barrier rejuvenation and repair.Nature reviews. Drug discovery · 2026Review
- Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period.Brain sciences · 2018Review
- Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions.Pharmacological reviews · 2018Review
- Alterations in inter-alpha inhibitor protein expression after hypoxic-ischemic brain injury in neonatal rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Article
- The significance of polymorphisms in genes encoding Il-1β, Il-6, TNFα, and Il-1RN in the pathogenesis of intraventricular hemorrhage in preterm infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Ischemia reduces inter-alpha inhibitor proteins in the brain of the ovine fetus.Developmental neurobiology · 2017Article
- Neutralizing anti-interleukin-1β antibodies reduce ischemia-related interleukin-1β transport across the blood-brain barrier in fetal sheep.Neuroscience · 2017Article
- HMGB1 Translocation After Ischemia in the Ovine Fetal Brain.Journal of neuropathology and experimental neurology · 2016Article
- Ontogeny of tight junction protein expression in the ovine cerebral cortex during development.Neuroscience · 2015Article
- Interleukin-1β transfer across the blood-brain barrier in the ovine fetus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Exploiting ovine immunology to improve the relevance of biomedical models.Molecular immunology · 2015Article
- Anti-IL-6 neutralizing antibody modulates blood-brain barrier function in the ovine fetus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia.Neurobiology of disease · 2015Article
- Review
- Gene-environment interactions in severe intraventricular hemorrhage of preterm neonates.Pediatric research · 2014Review
- Role of endogenous IL-6 in the neonatal expansion and functionality of Wistar rat pancreatic alpha cells.Diabetologia · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Interleukin (IL)-1β and IL-6 have been implicated in brain development, injury progression, and fetal/maternal immune interactions. We examined IL-1β and IL-6 protein expression in cerebral cortex (CC) and white matter (WM) from non-ischemic ovine fetuses at 87-90, 122-127, and 135-137 days of gestation, pregnant ewes at 87-90 and 135-137 days of gestation, and fetuses exposed to 48 or 72h of reperfusion after ischemia. Protein expression was determined by Western immunoblot. In non-ischemic CC, IL-1β was higher (P<0.05) in adult sheep and fetuses at 135-137 than 87-90 and 122-127 days, and IL-6 higher at 122-127 than 87-90 days, and in adults than fetuses at 87-90, 122-127, and 135-137 days of gestation. In non-ischemic fetal WM, IL-6 was higher at 135-137 than 87-90 days, but IL-1β did not differ. In CC, IL-1β was higher in ewes at 135-137 than 87-90 days and IL-6 at 135-137 days and in non-pregnant adults than ewes at 87-90 days of gestation. In WM, IL-1β was higher in ewes at 135-137 than 87-90 days of gestation, but IL-6 did not differ. Forty-eight and 72h after ischemia, CC IL-1β was higher than in non-ischemic fetuses. Seventy-two hours after ischemia, IL-1β and IL-6 were higher in WM than CC. In conclusion, IL-1β and IL-6 exhibit developmental regulation in fetal brain, change during gestation in brains of pregnant ewes, show regional differences in normal brains of fetuses and ewes, demonstrate differential responses after ischemia in CC and WM, and IL-1β but not IL-6 increases after ischemia in CC.
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