Trial reportDiabetes2012
B-type natriuretic peptide modulates ghrelin, hunger, and satiety in healthy men.
Trial report in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Brain Natriuretic Peptide on Appetite-regulating Hormones and Endothelial-derived Peptides
Effect of Nesiritide Infusion on Insulin Sensitivity in Healthy Obese Insulin Resistant Subjects
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Pooled it
- Acyl ghrelin improves cardiac function in heart failure and increases fractional shortening in cardiomyocytes without calcium mobilization.European heart journal · 2023Trial
- Role of angiotensin receptor-neprilysin inhibitor in diabetic complications.World journal of diabetes · 2024Review
- Synergistic effects of hormones on structural and functional maturation of cardiomyocytes and implications for heart regeneration.Cellular and molecular life sciences : CMLS · 2023Review
- A State of Natriuretic Peptide Deficiency.Endocrine reviews · 2023Article
- Pharmacologic blockade of the natriuretic peptide clearance receptor promotes weight loss and enhances insulin sensitivity in type 2 diabetes.Translational research : the journal of laboratory and clinical medicine · 2023Article
- Cardiac Remodeling and Its Determinants in Anorexia Nervosa Adolescents: Impact of Weight Recovery.Children (Basel, Switzerland) · 2022Article
- Six-year changes in N-terminal pro-brain natriuretic peptide and changes in weight and risk of obesity.Obesity (Silver Spring, Md.) · 2021Article
- The Importance of Natriuretic Peptides in Cardiometabolic Diseases.Journal of the Endocrine Society · 2020Review
- N-terminal Pro-B-Type Natriuretic Peptide and Malnutrition in Patients on Hemodialysis.International journal of nephrology · 2020Review
- Impact of renin-angiotensin-aldosterone system activation and body weight change on N-terminal pro-B-type natriuretic peptide variation in 100-km ultramarathon runners.Journal of the Chinese Medical Association : JCMA · 2020Article
- The role of brain natriuretic peptide during strenuous endurance exercise and appetite regulation.Journal of the Chinese Medical Association : JCMA · 2020Article
- Potential mechanisms of beneficial effect of sacubitril/valsartan on glycemic control.Therapeutic advances in endocrinology and metabolism · 2020Review
- Ghrelin Derangements in Idiopathic Dilated Cardiomyopathy: Impact of Myocardial Disease Duration and Left Ventricular Ejection Fraction.Journal of clinical medicine · 2019Article
- Metabolic effects of sacubitril/valsartan: are they relevant in clinical practice?Cardiovascular diagnosis and therapy · 2018Article
- Cardiomyokines from the heart.Cellular and molecular life sciences : CMLS · 2018Review
- Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI.BMC genomics · 2017Article
- The multifaceted role of natriuretic peptides in metabolic syndrome.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017Review
- Cardiac Natriuretic Peptides, Hypertension and Cardiovascular Risk.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2017Review
- NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients.International journal of nephrology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from ventricular cardiomyocytes. The pathophysiological mechanisms linking heart failure and appetite regulation remain unknown. In this study, we investigated the impact of intravenous BNP administration on appetite-regulating hormones and subjective ratings of hunger and satiety in 10 healthy volunteers. Participants received in a randomized, placebo-controlled, crossover, single-blinded study (subject) placebo once and 3.0 pmol/kg/min human BNP-32 once administered as a continuous infusion during 4 h. Circulating concentrations of appetite-regulating peptides were measured hourly. Subjective ratings of hunger and satiety were evaluated by visual analog scales. BNP inhibited the fasting-induced increase in total and acylated ghrelin concentrations over time (P = 0.043 and P = 0.038, respectively). In addition, BNP decreased the subjective rating of hunger (P = 0.009) and increased the feeling of satiety (P = 0.012) when compared with placebo. There were no significant changes in circulating peptide YY, glucagon-like peptide 1, oxyntomodulin, pancreatic polypeptide, leptin, and adiponectin concentrations. In summary, our results demonstrate that BNP exerts anorectic effects and reduces ghrelin concentrations in men. These data, taken together with the known cardiovascular properties of ghrelin, support the existence of a heart-gut-brain axis, which could be therapeutically targeted in patients with heart failure and obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.