Evidence map›Paper›PMID 22698259›Full record

ArticleJournal of the American Chemical Society2012

Discrete bimodal probes for thrombus imaging.

Ritika Uppal, Kate L Ciesienski, Daniel B Chonde, Galen S Loving, Peter Caravan

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Chemical science · 2015
    Article
  9. Review
  10. Potential clinical applications of bimodal PET-MRI or SPECT-MRI agents.Journal of labelled compounds & radiopharmaceuticals · 2014
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ritika UppalA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, Massachusetts 02129, USA.
Kate L Ciesienski
Daniel B Chonde
Galen S Loving
Peter Caravan
Massachusetts General Hospital · USHarvard University · US

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 1999 to 2011
$16.4M
PET Imaging of ThrombusR01HL109448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, SOSNOVIK, DAVID E · 2011 to 2025
$9.6M
Stable, High Relaxivity MRI Contrast AgentsR01EB009062 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2009 to 2017
$4.9M
Neuroimaging Training ProgramT32EB001680 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BRUCE R ROSEN · 2003 to 2026
$3.8M
NUCLEAR MAGNETIC RESONANCE RESEARCHT32CA009502 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MOORE, ANNA · 1985 to 2013
$2.0M
500 MHz NMR Spectrometer for Molecular Imaging ApplicationsS10RR023385 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2007 to 2007
$500k
IVIS Spectrum Imaging SystemS10RR025504 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI MOORE, ANNA · 2009 to 2009
$341k
NCI NIH HHS T32 CA009502NCI NIH HHS T32CA009502NCRR NIH HHS P41 RR014075NCRR NIH HHS P41RR14075NCRR NIH HHS S10 RR023385NCRR NIH HHS S10 RR025504NHLBI NIH HHS R01 HL109448NHLBI NIH HHS R01HL109448NIBIB NIH HHS R01 EB009062NIBIB NIH HHS R01EB009062NIBIB NIH HHS T32 EB001680
6 · The paper itself

Abstract

Here we report a generalizable solid/solution-phase strategy for the synthesis of discrete bimodal fibrin-targeted imaging probes. A fibrin-specific peptide was conjugated with two distinct imaging reporters at the C- and N-termini. In vitro studies demonstrated retention of fibrin affinity and specificity. Imaging studies showed that these probes could detect fibrin over a wide range of probe concentrations by optical, magnetic resonance, and positron emission tomography imaging.

Indexed as

FibrinFluorescein-5-isothiocyanateGadoliniumHumansMagnetic Resonance ImagingPeptidesPositron-Emission TomographyThrombosisEP-2104RFibrinFluorescein-5-isothiocyanateGadoliniumPeptides

Identifiers

PMID22698259
PMCPMC3397236
OpenAlexW2094778735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.