ArticleNano letters2012
Multicolor super-resolution DNA imaging for genetic analysis.
Article in Nano letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- SEM mapping of sequence-specific protein-DNA interactions on long DNA molecules.Nucleic acids research · 2026Article
- Single-Molecule Nanomechanical Genotyping with DNA Origami-Based Shape IDs.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Single-molecule optical genome mapping in nanochannels: multidisciplinarity at the nanoscale.Essays in biochemistry · 2021Article
- A single-molecule counting approach for convenient and ultrasensitive measurement of restriction digest efficiencies.PloS one · 2020Article
- Single-molecule DNA-mapping and whole-genome sequencing of individual cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Programming DNA origami assembly for shape-resolved nanomechanical imaging labels.Nature protocols · 2018Article
- DNA nanomapping using CRISPR-Cas9 as a programmable nanoparticle.Nature communications · 2017Article
- DNA origami-based shape IDs for single-molecule nanomechanical genotyping.Nature communications · 2017Article
- Superresolution Imaging of Clinical Formalin Fixed Paraffin Embedded Breast Cancer with Single Molecule Localization Microscopy.Scientific reports · 2017Article
- Ensemble and Single-Molecule Analysis of Non-Homologous End Joining in Frog Egg Extracts.Methods in enzymology · 2017Article
- Photobleaching of YOYO-1 in super-resolution single DNA fluorescence imaging.Beilstein journal of nanotechnology · 2017Article
- Analysis of single nucleic acid molecules in micro- and nano-fluidics.Lab on a chip · 2016Review
- Distribution of distances between DNA barcode labels in nanochannels close to the persistence length.The Journal of chemical physics · 2015Article
- Article
- Review
- A fast and scalable kymograph alignment algorithm for nanochannel-based optical DNA mappings.PloS one · 2015Article
- Small quantum dots conjugated to nanobodies as immunofluorescence probes for nanometric microscopy.Bioconjugate chemistry · 2014Article
- Toward single-molecule optical mapping of the epigenome.ACS nano · 2014Article
- Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.Endocrinology · 2013Article
- Super-resolution mbPAINT for optical localization of single-stranded DNA.ACS applied materials & interfaces · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Many types of cancer and neurodegenerative diseases are caused by abnormalities and variations in the genome. We have designed a high-resolution imaging technique with high throughput and low cost for determining structural variations of genes related to genetic diseases. We initially mapped all seven nicking sites of Nb.BbvCI endonuclease enzyme on lambda DNA. Then we resolved densely labeled patterns of 107 nicking sites on human BAC DNA that is digested by Nb.BsmI and Nb.BbvCI endonuclease enzymes. This high density resulted in several dyes being closer together than the diffraction limit. Overall, detailed DNA nicking sites mapping with 100 bp resolution was achieved, which has the potential to reveal information about genetic variance and to facilitate medical diagnosis of several genetic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.