ArticleCritical care (London, England)2012
Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season?
Article in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Benefit of Empiric Antiviral Treatment for Patients with Influenza-Associated Pneumonia Admitted to the Intensive Care Unit: A Retrospective Cohort Study.The American journal of tropical medicine and hygiene · 2025Article
- Use of Saliva Swab for Detection of Influenza Virus in Patients Admitted to an Emergency Department.Microbiology spectrum · 2021Article
- Prophylaxis and treatment of influenza: options, antiviral susceptibility, and existing recommendations.GMS infectious diseases · 2021Review
- Article
- [Influenza].Der Internist · 2019Review
- Clinical significance of lymphocytopenia in patients hospitalized with pneumonia caused by influenza virus.Critical care (London, England) · 2019Article
- Article
- Retrospective analysis of clinical and virological parameters of influenza cases at four university hospitals in Germany, 2015.Infection · 2017Article
- Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital.American journal of infection control · 2017Article
- Clinical practice of respiratory virus diagnostics in critically ill patients with a suspected pneumonia: A prospective observational study.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Observational
- Characterisation of nosocomial and community-acquired influenza in a large university hospital during two consecutive influenza seasons.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Observational
- The crucial role of molecular diagnostics.Deutsches Arzteblatt international · 2014Article
- In reply.Deutsches Arzteblatt international · 2014Article
- Year in review 2012: Critical Care--respiratory infections.Critical care (London, England) · 2013Review
- Circulation of other respiratory viruses and viral co-infection during the 2009 pandemic influenza.Enfermedades infecciosas y microbiologia clinica · 2012Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInfluenza is easily overlooked in intensive care units (ICUs), particularly in patients with alternative causes of respiratory failure or in those who acquire influenza during their ICU stay.
methodsWe performed a prospective study of patients admitted to three adult ICUs of our hospital from December 2010 to February 2011. All tracheal aspirate (TA) samples sent to the microbiology department were systematically screened for influenza. We defined influenza as unsuspected if testing was not requested and the patient was not receiving empirical antiviral therapy after sample collection.
resultsWe received TA samples from 105 patients. Influenza was detected in 31 patients and was classified as unsuspected in 15 (48.4%) patients, and as hospital acquired in 13 (42%) patients. Suspected and unsuspected cases were compared, and significant differences were found for age (53 versus 69 median years), severe respiratory failure (68.8% versus 20%), surgery (6.3% versus 60%), median days of ICU stay before diagnosis (1 versus 4), nosocomial infection (18.8% versus 66.7%), cough (93.8% versus 53.3%), localized infiltrate on chest radiograph (6.3% versus 40%), median days to antiviral treatment (2 versus 9), pneumonia (93.8% versus 53.3%), and acute respiratory distress syndrome (75% versus 26.7%). Multivariate analysis showed admission to the surgical ICU (odds ratio (OR), 37.1; 95% confidence interval (CI), 2.1 to 666.6; P = 0.01) and localized infiltrate on chest radiograph (OR, 27.8; 95% CI, 1.3 to 584.1; P = 0.03) to be independent risk factors for unsuspected influenza. Overall mortality at 30 days was 29%. ICU admission for severe respiratory failure was an independent risk factor for poor outcome.
conclusionDuring the influenza season, almost one third of critical patients with suspected lower respiratory tract infection had influenza, and in 48.4%, the influenza was unsuspected. Lower respiratory samples from adult ICUs should be systematically screened for influenza during seasonal epidemics.
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